夫妻中男性伴侣长期接受抗

肿瘤坏死因子-α抑制剂治疗的

妊娠结果：一项前瞻性研究

目的

分析暴露于TNFi的脊柱关节炎的男性配偶的妊娠结果。

方法

对6个罗马尼亚风湿研究中心的男性配偶进行妊娠数据的前瞻性分析。

结果

研究纳入27名患者，共妊娠33次，30名健康儿诞生。三次妊娠患者由于个人原因选择终止妊娠，未发生自发性流产、先兆子痫、子痫、死产、先天畸形或婴儿疾病。五位患者在接受长期TNFi治疗前后精子正常。

结 论

长期接受TNFi治疗的男性脊柱关节炎患者对妊娠结果和新生儿的健康没有影响。

原 文

Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti–tumor Necrosis Factor–α Inhibitor Therapies: A Prospective Study

Objective

To examine the pregnancy achievement and outcomes in couples in which men with spondyloarthritis (SpA) were exposed to tumor necrosis factor inhibitors (TNFi).

Methods

Information about pregnancies involving fathers with SpA was prospectively collected by 6 Romanian rheumatology centers.

Results

Twenty-seven patients achieved 33 pregnancies and fathered 30 healthy children. Three elective abortions (personal reasons) and no spontaneous abortions, preeclampsia/eclampsia, stillbirths, congenital malformations, or pathologies in the children were recorded. Five patients showed normospermia before and after longterm TNFi treatment.

Conclusion

Pregnancy and child outcomes in male patients with SpA exposed to longterm TNFi therapy were reassuring.

文章出处:

http://www.jrheum.org/content/46/9/1084

作者：Mihaela C. Micu, Monika Ostensen, Violeta Bojincă, Oana Șerban, Minodora Mihai, Cristina Suța, Anamaria Ramazan, Luminița Enache, Anca Bobircă, Sergiu F. Pătcaș, Romeo Micu and Ruxandra Ionescu

杂志：The Journal of Rheumatology September 2019, 46 (9) 1084-1088; DOI: https://doi.org/10.3899/jrheum.180588