恶性肿瘤可能与抗磷脂抗体阳性有关，但单纯表现为产科并发症的抗磷脂综合征的癌症发病率目前尚不清楚。我们的目的是调查在转诊于大学医院队列(NOH-APS队列)中有产科抗磷脂综合征病史的女性癌症的发生率。

我们对1592名在10周之前连续三次自然流产或10周之后一次胎儿死亡的非血栓性妇女进行了为期17年的观察性研究。比较以下三个队列在随访期间癌症发生率：抗磷脂抗体阳性的队列女性(n = 517)，携带F5 rs6025或F2 rs1799963多态性(n = 279)的队列女性和血栓形成倾向阴性筛查结果的队列女性(n =796)。

产科抗磷脂综合征患者的年癌症发病率为0.300%(0.20%-0.44%)。与患有血栓形成倾向阴性的女性相比，其癌症风险显著升高[调整风险比aHR：2.483，95%置信区间(CI)1.27-4.85]。计算出的产科抗磷脂综合征妇女的标准化发病率为2.89，95%CI为1.89-4.23。在抗磷脂抗体中，狼疮抗凝物(aHR 2.608，95%CI：1.091-6.236)与癌症相关。

我们的队列研究证明，与普通人群、初始临床病史相似但抗磷脂抗体阴性的女性相比，有产科抗磷脂综合征病史的女性患癌症的风险显著升高

附原文:

Malignancies can be associated with positive antiphospholipid antibodies but cancer incidence in the purely obstetric form of antiphospholipid syndrome is currently unknown. Our aim was to investigate the comparative incidence of cancers in women with a history of obstetric antiphospholipid syndrome within a referral university hospital-based cohort (NOH-APS cohort).

We performed a 17-year observational study of 1592 nonthrombotic women with three consecutive spontaneous abortions before the 10thweek of gestation or one fetal death at or beyond the 10thweek of gestation. We compared the incidence of cancer diagnosis during follow-up among cohort women positive for antiphospholipid antibodies (n=517), cohort women carrying the F5 rs6025 or F2 rs1799963 polymorphism (n=279) and cohort women with negative thrombophilia screening results (n=796).

The annualized rate of cancer was 0.300% (0.20%-0.44%) for women with obstetric antiphospholipid syndrome and their cancer risk was substantially higher compared to the one of women with negative thrombophilia screening [adjusted hazard ratio aHR: 2.483, 95% confidence interval (CI) 1.27-4.85]. The computed standardized incidence ratio for women with obstetric antiphospholipid syndrome was2.89, 95% CI 1.89-4.23. Among antiphospholipid antibodies, lupus anticoagulant (aHR 2.608, 95%CI 1.091-6.236) was associated with incident cancers.

Our cohort study evidences a substantially higher risk of cancer in women with a history of obstetric antiphospholipid syndrome compared to the general population, and compared to women with a similar initial clinical history but negative for antiphospholipid antibodies.

引自：Jean-Christophe Gris, .ve Mousty, Sylvie Bouvier, et al.Increased incidence of cancer in the follow-up of obstetric antiphospholipid

syndrome within the the NOH-APS cohort.