肠道微生物菌群影响非肠道相关性自身免疫性疾病
摘 要:
人体被数百万的微生物菌群定居,这些微生物体以合作和非致病的方式与我们的组织相互作用。这些微生物存在于皮肤,肠道,鼻腔, 和生殖道中。
实际上,已经描述了微生物群有助于平衡免疫系统以维持宿主体内平衡。肠道是重要器官,微生物群可以影响和决定免疫系统细胞功能并有助于维护个体健康。
几篇文章强调了肠道自身免疫疾病之间的联系,例如克罗恩氏病与生态失调或肠道内微生物组成的不平衡。然而,关于微生物群在影响其他组织的自身免疫病理学中作用的知之甚少,而不是肠道。
本文重点介绍肠道微生物群在非肠道自身免疫性疾病如格雷夫斯病,多发性硬化症,1型 ,系统性红斑狼疮,银屑病,精神分裂症和自闭症谱系障碍的发病机制中可能发挥的作用。此外,我们讨论如何从细菌衍生的代谢物可用作非肠道自身免疫性疾病的潜在疗法。
参考文献:
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases.
Abstract
The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin,gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. Thegutis a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in thegut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role thatgutmicrobiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes,systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived frombacteriacould be used as potential therapies for non-intestinal autoimmune diseases.
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