摘要 ：

        我们对系统性红斑狼疮与早产进行了一项荟萃分析。在这项研究中，我们研究了

        SLE疾病本身的影响，SLE的疾病活动度、肾脏受累及活动性肾炎对早产的影响。检索在2016年5月20日前发表在Pubmed、Embase、MEDLINE及Cochrane数据库里所有相关文献，共有十一例观察性病例对照研究和十三项队列研究符合纳入标准。SLE患者合并早产的相对风险(RR)是健康对照组的2.05倍(95%可信区间：1.72–3.32);病情活动SLE患者的相对风险是病情稳定SLE患者的2.98倍(95% 可信区间: 2.32–3.83)。患有狼疮肾炎的SLE患者合并早产的相对风险是无狼疮肾炎的SLE患者的1.62倍(95% 可信区间: 1.35–1.95);患有活动性狼疮肾炎的SLE患者合并早产的相对风险是狼疮肾炎处于静止期的SLE患者的1.78倍(95% 可信区间: 1.17–2.70)总之，这项研究在上述结果中发现了显著的关联性，而且这种相关性在活动性SLE患者较非活动患者中更为显著。就SLE疾病本身而言，活动性炎症(如疾病活动)对妊娠的影响可能更为危险。这表明为达到更好的妊娠结局控制疾病活动是非常必要的。

        附原文：

        We performed a meta-analysis to identify the association between systemic lupus erythematosus(SLE) and preterm birth. In this study, we studied the effects of SLE, SLE disease activity, a history of nephritis and active nephritis on preterm birth. Searches were conducted before 20 May 2016 of PubMed, Embase, Medline and Cochrane Library of literature and article reference lists. Eleven observational case–control studies and thirteen cohort studies met the inclusion criteria. The pooled relative risk (RR) for the riskof preterm birth in SLE patients versus controls was 2.05 (95% confidenceinterval (CI): 1.72–3.32); for active SLE patients versus inactive was 2.98 (95% CI: 2.32–3.83); for SLE patients with a history of lupus nephritis versus those without nephritis it was 1.62 (95% CI: 1.35–1.95); and for SLE patients with active nephritis versus those with quiescent nephritis it was 1.78 (95% CI: 1.17–2.70). In summary, this study identified a significant association in the above results. This association was more significant in active SLE patients versus inactive. With respect to SLE itself, active inflammation(such asdisease activity) may be more hazardous for the management of the pregnancy. This suggests that it is essential to control disease activity in order to achieve a better outcome of SLE pregnancy.

        引自：Wei S, Lai K, Yang Z, et al. Systemic lupus erythematosus and risk of preterm birth: a systematic review and meta-analysis of observational studies[J]. Lupus, 2017, (2017) 26, 563–571.