摘要 ：

        目前，肺部受累的系统性红斑狼疮患者缺乏相关的生物学标志物。收集9例肺部受累的SLE患者(SLEpulm)的血浆标本及9例无肺部受累的SLE患者(SLE)的血浆标本通过多重微阵列方法分析各种细胞因子及趋化因子的表达情况。与无肺部受累的SLE患者相比，肺部受累的SLE患者表现为肺功能参数如用力肺活量(FVC)、肺总量(TLC)、一氧化碳弥散量(DLCO)和CO对肺容积修正扩散(KLCO)显著降低，而CC趋化因子配体21(CCL21)和γ干扰素诱导蛋白10(IP-10)表达水平明显升高。CCL21表达水平与DLCO呈负相关(r=-0.73;p<0.01)，与KLCO 呈负相关(r=-0.62; p<0.01);而IP-10与FVC及第一秒用力呼气量呈负相关。采用受试者工作特征曲线(ROC曲线)分析CCL21、IP-10对于区分合并肺部受累的SLE患者及无肺部受累SLE患者的敏感性和特异性(曲线下面积(AUC))：CCL21 (AUC：0.85;灵敏度%：88.90;特异性%：75.00;p<0.01);IP-10(AUC：0.82;灵敏度%：66.67;特异性%：100;p<0.01)。合并肺部受累的SLE患者的肺功能及DLCO/KLCO变化与CCL21和IP-10的显著增加有关。这些趋化因子可能是SLE患者肺部受累的潜在生物标志物。

        附原文：

        Biomarkers for pulmonary manifestations in systemic lupus erythematosus (SLE) are missing. Plasma samples of nine SLE patients with known pulmonary involvement (SLEpulm) and nine SLE patients without pulmonary involvement (SLE) were tested by multiplex microarray analysis for various cyto- and chemokines. Significantly decreased lung function paramters for forced vital capacity (FVC), total lung capacity(TLC), diffusion capacity for carbonmonoxide (DLCO) and diffusion of CO corrected on lung volume (KLCO) were observed inSLE pulmas compared to SLE patients. CC chemokine ligand 21 (CCL21) and interfer ongamma-inducedprotein 10 (IP-10) levels were significantly higher in SLE pulm than in patients without pulmonary manifestations. CCL21 correlated negatively with DLCO (r=-0.73;p<0.01) and KLCO (r=-0.62; p<0.01), while IP-10 with FVC and forced expiratory volume one second. Receiver Operating Characteristics (ROC) analysis confirmed high sensitivity and specificity for the separation of SLE patients with and without pulmonary involvement for the chemokines CCL21 (Area Under Curve (AUC): 0.85; sensitivity%: 88.90; specificity%: 75.00; p<0.01) and IP-10 (AUC: 0.82; sensitivity%: 66.67, specificity %: 100;p<0.01). Pleuro pulmonary manifestations in SLE patients associated with lung functionaland DLCO/KLCO changes and were associated with significant increase in CCL21 and IP-10. These chemokines might serve as potential biomarkers of lung involvement in SLE patients.

        引自：Odler B, Bikov A, Streizig J, et al. CCL21 and IP-10 as blood biomarkers for pulmonary involvement in systemic lupus erythematosus patients [J]. Lupus, (2017) 26, 572–579.