摘要 目的：大动脉炎(TA)是一种通常影响年轻女性的疾病，其特征在于大血管受累的炎症和缺血征象，包括颅外脑动脉。目前中风对TA预后的影响尚未得到很好的评估。

        方法：我们对患有至少一次卒中的TA患者进行了回顾性多中心评估，并将其与17名匹配的无神经系统受累的TA患者进行比较。

        结果：从126例诊断为大动脉炎患者中最终筛选出17例存在卒中的大动脉炎患者。在诊断时，两组患者均比较了心血管危险因素。第一脑血管事件是缺血性卒中(N=15)或短暂性脑缺血发作(N=2)。8例患者中卒中发生在大动脉炎诊断后，4例患者卒中发生在颈动脉手术后。随访结束时，59%的患者存在神经功能障碍，35%的存在卒中复发，24%的患者存在癫痫发作。

        结论：卒中是大动脉炎患者残疾的主要原因。由于颈内动脉手术后存在脑卒中发生的风险，故此手术需谨慎进行。

        附原文：Objectives Takayasu arteritis (TA) is a giant cell arteritis usually affecting young women and characterized by inflammatoryand ischemic signs of large vessel involvement, including extracranial cerebral arteries. The impact of stroke on TAprognosis has not been well evaluated.Methods We performed a retrospective multicenter review of patients with definite TA who experienced at least one strokeand compared the findings to 17 matched patients with TA diagnosis without neurological involvement.Results Seventeen patients (15 women, median age at stroke diagnosis 44 years) receiving a diagnosis of TA and strokebetween 2002 and 2016 in our institution were included, from a cohort of 126 patients suffering from TA (13.5%). At diagnosis,patients from both groups had comparable cardiovascular risk factors. The first cerebrovascular event was ischemicstroke (n = 15) or transient ischemic attack (n = 2). In eight patients, stroke occurred after the TA diagnosis was made. Infour patients, stroke occurred after carotid surgery. At the end of follow-up, 59% of patients had a neurological impairment,35% had a recurrence of stroke, and 24% suffered from epilepsy.Conclusions Stroke is a major cause of disability in TA patients. Internal carotid surgery may be performed with cautionbecause of the risk of stroke after the procedure.

        引自：Priscille CoutureCerebrovascular events in Takayasu arteritis: a multicentercase‑controlled studyJournal of Neurology