摘要：为评估低强度激光治疗(LLLT)原发性干燥综合征患者口干的疗效，进行一项随机临床研究。该研究纳入66名某大学医院诊断原发性干燥综合征合并口干症状的患者，随机分为两组，一组接受LLLT(激光组，n=33)，另一组接受安慰剂治疗(安慰剂组，n=33)。激光组接受LLLT一周两次共6周，共12次治疗。用铝镓砷化物激光二极管进行激光照射，波长为808纳米，输出功率为100毫瓦，每次照射点的能量密度为4焦耳/厘米。安慰剂治疗采用与放疗病人相同的方案，使用相同的激光装置模拟真实辐射，但没有主动激光发射，激光探针覆盖铝箔。评估口干症量表评分、唾液流率、唾液β2-微球蛋白水平、唾液钠和氯的浓度。结果显示，口干症状在两组均无改善。同样，口干症量表评分(p=0.301)、唾液流率(p=0.643)在两组均无改善。唾液β2-微球蛋白、钠浓度、氯浓度在治疗前后及两组之间均无显著差异。LLLT治疗不能改善原发性干燥综合征患者口干或唾液流率。

        附原文：Abstract To evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjögren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions. Laser irradiation was performed with an aluminum-gallium-arsenide laser diode at a wavelength of 808 nm, 100-mW output power, and energy density of 4.0 J/cm2 per irradiation point per session. Placebo treatment was performed following the same protocol used for irradiated patients and using the same laser device to mimic a real irradiation, but with no active laser emission and the tip of the laser probe covered with aluminum foil. The outcomes of interest were xerostomia inventory scores, salivary flow rate, salivary beta-2 microglobulin levels, and salivary sodium and chlorine concentrations. Patients in both groups showed no improvement in xerostomia. Likewise, there was no significant improvement in xerostomia inventory scores (p = 0.301) or salivary flow rate (p = 0.643) in either group. There was no difference in salivary beta-2 microglobulin levels, sodium concentration, and chlorine concentration before and after intervention or between the two groups. The LLLT protocol used in this study effected no improvement in xerostomia or salivary flow rate in patients with primary SS. ClinicalTrials.gov Identifier: NCT02066896.

        引自：Fidelix T, Czapkowski A, Azjen S, et al. Low-level laser therapy for xerostomia in primary Sjögren's syndrome: a randomized trial. Clin Rheumatol. 2018 Mar;37(3):729-736. doi: 10.1007/s10067-017-3898-9. Epub 2017 Nov 9.