摘要 ：

背景：复发性流产的发生率很高， 30%-40%的发病原因不明。子宫动脉的高阻力被认为是复发性流产的原因之一。

目的：明确维生素E和阿司匹林对因子宫动脉血流减少导致复发性流产的女性子宫动脉血流的影响。

方法：该单盲随机临床试验对象是99个子宫动脉搏动指数大于2.5，并且有两次以上流产史的女性。这些人按分类分为三组：阿司匹林组，维生素E组，阿司匹林+维生素E组。两个月后比较各组之间的子宫动脉搏动指数。

结果：所有药物治疗均增加了子宫动脉灌注，明显减少了子宫动脉搏动指数。口服维生素E的妇女子宫动脉平均PI最低(p<0.001)。服用维生素E组与阿司匹林组比较，左、右子宫动脉的总平均PI评分显著低于对照组(p<0.001)。

结论：维生素E与阿司匹林联用时，可以增加因子宫动脉血流减少而反复流产的女性的子宫动脉灌注，显著降低子宫动脉搏动指数。但该结论需要更多更好的设计研究，增加子宫动脉灌注是否会有更好的妊娠结局仍有待进一步明确。

附原文：

BACKGROUND:Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterineartery resistance is accounted as one of the recurrent abortion reasons.

OBJECTIVE: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow.

MATERIALS AND METHODS:This randomized clinicaltrial was conducted on 99 women having uterine pulsatility index (PI) more than 2.5 and the history of more than two times abortions. The candidates were categorized into three groups: receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs were compared with each other.

RESULTS:All drug regimens caused an enhancementin uterine perfusion with a significant decline in uterine artery PI value. The women receiving vitamin E in accompanied with aspirin had the least mean PI of the uterine artery (p<0.001). The total average PI score of the right and left uterine arteries in groups receiving vitamin E in accompanied with aspirin was lower than the two counter parts significantly (p<0.001).

CONCLUSION:Vitamin E, aspirin and especially their combination are effective in improving uterine artery blood flow in women with recurrent abortion due to impaired uterine blood flow. More well-designed studies are needed to find out whether the enhancement of uterine perfusion may lead to a better pregnancy outcome.

引自：MesdaghiniaE, et al. The effect of vitamin E and aspirin on the uterine artery blood flowin women with recurrent abortion: A single-blind randomized controlled trial. Int J Reprod Biomed (Yazd). 2017 Oct;15(10):635-640.