摘要 ：目的：旨在评估类风湿关节炎(RA)患者中188bet在线平台网址 的发病率及188bet在线平台网址 对自身健康状况的整体影响。

        方法：从全国法定健康保险基金随机选取18岁至79岁年龄段的RA患者，并对其进行随访调查有关风湿病诊治及疾病负担方面的情况。根据年龄、性别、BMI及社会经济学状态分析合并疾病188bet在线平台网址 的相关情况。比较RA合并与RA不合并188bet在线平台网址 患者之间在疾病负担、伴随疾病和用药方面的差异。通过多元回归分析确定风湿病治疗的预测因素。

        结果：在2535例RA患者中有498例(20%)患者合并了188bet在线平台网址 。188bet在线平台网址 尤为多见于男性、老年、高BMI以及社会经济状况低下的患者群体。在RA合并188bet在线平台网址 的患者中患者的预后均不好，且主要可能与高BMI有关。RA合并188bet在线平台网址 患者较单纯RA患者接受更少的DMARDs和住院天数也更多。RA合并188bet在线平台网址 的患者中心血管疾病、抑郁和肾衰竭的发生率更高。经混杂因素校正后，RA合并188bet在线平台网址 患者更少接受风湿病专科医生的治疗(57% vs 67%)。

        结论：RA患者中188bet在线平台网址 的发生率很高，且与已知的社会经济学因素有关。超过40%的RA合并188bet在线平台网址 的患者并没有接受风湿科专业医生的诊治，尽管研究提示这部分患者的疾病负担很高、经常住院和通常有更多的合并症。

        附原文：Abstract Objectives: To investigate the prevalence ofdiabetes in patients with RA and the impact of diabetes on self-reportedoutcomes and health care. Methods: RA patients between the ages of 18 and 79years were randomly selected from a nationwide statutory health insurance fundand were surveyed about rheumatological care and disease burden. Comorbiddiabetes (E10-14) was analysed regarding age, sex, BMI and socioeconomicstatus. Disease burden, comorbidity and prescriptions were compared in RApatients with and without diabetes. Predictors of rheumatological care wereidentified by multivariate regression. Results: Of the 2535 RA patients, 498(20%) had diabetes. Diabetes was more frequent in males, in older patients, in patientswith a higher BMI and in those with a lower socioeconomic status. All diseaseoutcomes were poorer in RA-diabetes patients and were mainly attributable to ahigher BMI. RA-diabetes patients received less DMARDs (40% vs 48%) and had morehospital stays (41% vs 30%) than patients without diabetes (all P < 0.05).Rates of cardiovascular disease (35% vs 15%), depression (39% vs 26%) and renalfailure (23% vs 8%) were higher in RA-diabetes patients (all P < 0.0001).They were less frequently treated by rheumatology specialists: 57% vs 67%; oddsratio = 0.64 (95% CI: 0.45, 0.92), after controlling for confounders. Conclusion:The prevalence of diabetes in patients with RA is high and is associated withknown sociodemographic factors. More than 40% of patients with RA and diabeteswere not under rheumatological care even though they reported a high diseaseburden, were frequently hospitalized and often presented with furthercomorbidities.

        引自：Albrecht K,Luque Ramos A,Hoffmann F,Redeker I,Zink A. High prevalence of diabetes in patients withrheumatoid arthritis: results from a questionnaire survey linked to claimsdata.Rheumatology (Oxford).2018 Feb 1;57(2):329-336. doi:10.1093/rheumatology/kex414.