肥胖与类风湿关节炎有关联？
【前沿进展】肥胖与类风湿关节炎有关联？
摘要：世界范围内，不断增长的肥胖流行病导致一系列慢性病。最近的流行病学研究表明，肥胖与类风湿性关节炎(RA)发病之间的关联，特别是在年轻女性中，由此脂肪因子的促炎作用提供了一种解释性假说。然而，最近的基于临床和实验室的研究提供了显示，微生物组参与RA起始和发展(包括抗瓜氨酸化抗体形成和Th17细胞活化)的新兴证据。肥胖和RA相关微生物组的改变可能提供一个合理的联系来解决肥胖对RA发病机制的影响。本文介绍了微生物组对RA发展的影响 - 在粘膜和关节部位 -以及与肥胖症与RA关联的相关病理生理机制，以讨论该假说并帮助了解肥胖在RA发展中的作用。
附原文：Abstract：Worldwide, the growing obesity pandemiccontributes to a range of chronic diseases. Recent epidemiological studies havesuggested an association between obesity and the development of rheumatoid arthritis(RA), particularly among young women, whereby pro-inflammatory effects ofadipokines provide one explanatory hypothesis. Yet, recent clinical andlaboratory-based studies provide emerging evidence indicating microbiomeinvolvement in RA initiation and development, including anti-citrullinatedantibody formation and Th17 cell activation. Obesity and RA-associatedmicrobiome alteration might provide a plausible link to address the impact ofobesity to RA pathogenesis. The microbiome's influence on RA development - atmucosal as well as articular sites - and relevant pathophysiological mechanismsregarding obesity's association with RA are presented herein to discuss thishypothesis and aid understanding of obesity's role in RA development.
引自：Luo Y,Blackledge WC.Microbiome-based mechanisms hypothesized to initiate obesity-associated rheumatoid arthritis.Obes Rev.2018 Feb 9. doi: 10.1111/obr.12671. [Epub ahead of print]
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