严重过敏性疾病与成功妊娠之间的因果关系目前尚不清楚。此研究旨在评估在特应性疾病(AD)实验小鼠模型中生殖表现以及对胎盘形成中起关键作用的自然杀伤细胞的出现情况。在存在中度皮肤过敏性病变的NC/Nga怀孕小鼠中我们检测到IgE水平有8.6倍升高。在正常胎儿数目、流产率以及胎盘大小上未检测到明显的差异。在特应性疾病小鼠模型的胎盘中几乎没有自然杀伤细胞。并且与对照组相比，未成熟的胎盘中有着明显的降低。这些研究结果表明，虽然没有妊娠过程，但特应性疾病干扰子宫自然杀伤细胞的分化并对胎盘的形成有不利影响。上述表现或许可能是在特应性疾病背后特定的免疫条件调控有利于生殖能力的恢复。

        附原文

        ABSTRACT. The causal relationship between severe allergic conditions and successful pregnancy remains unclear. We aimed to evaluate reproductiveperformance in an experimental mouse model of atopic disease (AD), and the appearance of uterine natural killer (uNK) cells thathave crucial roles in placental formation was examined. In the NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-foldelevation of plasma IgE, significant differences were not detected in the reproductive indices of the number of normal fetuses, abortion rateand placental size. There were few uNK cells in the placenta of AD mice, and they showed a significant decrease regarding the immaturesubtype as compared with controls. These findings revealed that AD disturbs uNK cell differentiation and provides disadvantageous effectson placental formation, although it does not arrest the pregnancy process. It may be possible that specific immunological conditions behindAD operate favorably to recover the reproductive performance.

        引自

        Kazuhiko HAYASHI, Ken Takeshi KUSAKABE, Satoko SUGIMOTO

        Influence of Atopic Dermatitis on Reproduction and Uterine Natural Killer Cellsdoi: 10.1292/jvms.13-0547; J. Vet. Med. Sci. 76(6): 913–916, 2014.