据推测，先天性心脏阻滞是由母体的抗Ro/SSA 52 kd, p200,Ro/SSA 60 kd, La/SSB核蛋白通过胎盘传送而引起的自身抗体调节紊乱所致。本研究调查独立的Ro52/SSA，p200，Ro60/SSA和抗La/SSB抗体阳性在孕妇中的临床意义。163个Ro52/SSA，p200，Ro60/SSA或抗La/SSB抗体阳性的女性被纳入，进行前瞻性的研究。Ro52/SSA，p200，Ro60/SSA和抗La/SSB通过ELISA进行化验。25个女性出现了单个抗体阳性(15.3%)，138个人出现了多样抗体阳性(84.7%)。24个出现了心脏传导阻滞，139个出现了良好的结局。单个抗Ro60抗体阳性出现心脏阻滞的发病率较低于平均抗体滴度(p<0.0001)的其他组显著增高(p<0.046)。通过这个大型研究的结果，提示临床不必对单个R060/SSA阳性母亲的胎儿进行严格的超声监测。

        附原文：Congenitalheart block (CHB) is an autoantibody mediated disorder presumably caused byplacental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA60 kd, La/SSB ribonucleoproteins.This study investigated the clinicalsignificance of isolated anti-Ro/SSA 52 kd,anti-p200, anti-Ro/SSA 60 kd, andanti-La/SSB antibodiesin positive pregnant patients.One hundred sixtythree pregnantwomen positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSBantibodies were prospectively enrolled in the study. Anti-Ro52, anti-Ro60,anti-p200, and anti-La antibodies were assayed using home-made ELISA assays.Isolated antibody positivity was found in 25 women (15.3%), while multiple antibodypositivity in 138 (84.7%). Twenty-four developed CHB, and the 139 had afavorable pregnancy outcome.The prevalence of isolated anti-Ro/SSA 60 kd antibodieswas significantly higher (p < 0.046) as the prevalence of lower meanantibody titers (p < 0.0001) in the later group. Confirmation of theseresults by large-scale studies could lead clinicians to recommend lessstringent fetal echocardiography monitoring in women with isolated anti-Ro/SSA60 kd antibodies.

        引自：MartaTonello1 et al.Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated withpositive pregnancy outcomes in women at risk of congenital heart block.Clin Rheumatol.2017 May;36(5):1155-1160.