IL-33和ST2与成人Still疾病活动度相关
前沿进展丨血清IL-33和可溶性ST2与成人斯蒂尔病患者的疾病活动度相关
目的：白介素33（IL-33）是IL-1家族的成员和孤儿受体ST2的配体，在先天和适应性免疫中起关键作用。我们调查了IL-33 / ST2水平与活动性成年Still病（AOSD）患者临床表现之间的关系。
方法：从40例活动性AOSD患者，28例类风湿关节炎患者（RA）和27例健康对照（HC）中收集血样。使用ELISA方法测定IL-33和可溶性ST2的血清水平。从34例存在皮疹的AOSD患者中获得活检标本，通过免疫组织化学研究IL-33和ST2的表达水平。
结果：AOSD患者的IL-33水平高于RA和HC患者。 AOSD患者的可溶性ST2水平高于HC，而非RA患者。血清IL-33水平与全身评分，红细胞沉降率，铁蛋白水平和天冬氨酸转氨酶水平相关。然而，血清可溶性ST2水平仅与铁蛋白水平相关。与HC相比，AOSD患者的皮损中表达IL-33和ST2的炎性细胞数量升高，但与湿疹或牛皮癣皮损处细胞表达没有差异。
结论：我们发现活动性AOSD患者的血清IL-33和可溶性ST2水平显着升高。结果表明IL-33 / ST2信号通路可能在AOSD相关的急性炎症和皮肤表现的发病机制发挥作用。
附原文：
OBJECTIVE: Interleukin 33 (IL-33), a member of the IL-1 family and a ligand of the orphan receptor ST2, plays key roles in innate and adaptive immunity. We examined the associations between IL-33/ST2 levels and clinical manifestations of patients with active adult-onset Still's disease (AOSD).
METHODS: Blood samples were collected from 40 patients with active AOSD, 28 patients with rheumatoid arthritis (RA), and 27 healthy controls (HC). The serum levels of IL-33 and soluble ST2 were determined using ELISA. Expression levels of IL-33 and ST2 in biopsy specimens obtained from 34 AOSD patients with rash were immunohistochemically investigated.
RESULTS:IL-33 levels of patients with AOSD were higher than those of patients with RA and HC. Soluble ST2 levels of patients with AOSD were higher than those of HC, but not of patients with RA. Serum IL-33 levels correlated with systemic score, erythrocyte sedimentation rate, ferritin levels, and aspartate transaminase levels. However, serum soluble ST2 levels correlated only with ferritin levels. The numbers of inflammatory cells expressing IL-33 and ST2 were elevated in skin lesions of patients with AOSD compared to HC, but did not differ from those of the skin lesions of eczema or psoriasis.
CONCLUSION:We found significantly higher serum IL-33 and soluble ST2 levels in patients with active AOSD. Results indicate that the IL-33/ST2 signaling pathway may play a role in the pathogenesis of the acute inflammation and skin manifestations associated with AOSD.
引自：Han JH1, Suh CH1, Jung JY1,et al.Serum Levels of Interleukin 33 and Soluble ST2 Are Associated with the Extent of Disease Activity and Cutaneous Manifestations in Patients with Active Adult-onset Still's Disease.Rheumatol. 2017 Apr 1. pii: jrheum.170020. doi: 10.3899/jrheum.170020. [Epub ahead of print]
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