Lancet Respiratory Medicine. 2022 Jul 27; PMID: 35907424

Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study.

Tessa M Kole, Elise Vanden Berghe, Monica Kraft, et al

哮喘患者可以发生持续气流受限，不仅是严重哮喘，相当比例的较轻的哮喘患者也可以有。对这样的患者应谨慎诊断慢阻肺，在我国2021版慢阻肺指南的诊断流程中，戴帽前还有一步，“排除其他诊断”。如果没有吸烟等危险因素暴露、没有肺气肿，肺功能符合哮喘病理生理和临床过程，有什么理由诊断慢阻肺呢?

European Respiratory Journal. 2022 Aug 4; PMID: 35926878

Sensitisation to recombinant Aspergillus fumigatus allergens and clinical outcomes in COPD.

Pei Yee Tiew, Jayanth Kumar Narayana, Marilynn Swee Li Quek, et al

Chest. 2022 Jul 31; PMID: 35921883

Association of Inhaled Corticosteroids With All-cause Death Risk in COPD Patients: A Meta-analysis of Sixty Randomized Controlled Trials.

Hong Chen, Zheng-Xu Deng, Jian Sun, et al

这项研究的亮点在于分析了获益亚组和预测因素，有助于含ICS吸入治疗的个体化应用。非常有意思的是再一次验证了规范坚持治疗的重要性。另外，就EOS 100-300的灰区怎么结合临床，给出了量化指标。再者，ICS怎么选，对高剂量say no，倾向抗炎作用不是最强的品种：(1)验证了ETHOS研究降中重度AE，低剂量三联≈高剂量三联>高剂量ICS/LABA;(2)支扩剂的backbone地位并没有变。BMI太低的患者，没有保护作用，则可能和肺炎发生风险升高有关。对于ICS在慢阻肺中的应用，老文章还没有过时：长期使用ICS的潜在肺炎风险，你怎么看?

Chest. 2022 Aug 8; PMID: 35952766

Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trial.

Anja Frei, Thomas Radtke, Kaba Dalla Lana, et al

大多数慢阻肺患者在肺部康复(PR)后未能维持运动训练(PR的强度的确不太能坚持图片)，那么在家进行最低限度的设备力量训练是不是也有获益呢?这项研究尽管主要终点呼吸困难没有改善，但是做做运动至少心情能好啊，体能表现也好一些。

Thorax. 2022 Aug 10; PMID: 35948418

Oscillatory positive expiratory pressure therapy in COPD (O-COPD): a randomised controlled trial.

Saeed M Alghamdi, Abdullah S Alsulayyim, Ali M Alasmari, et al

European Respiratory Journal. 2022 Jul 26; PMID: 35896207

Detection of COPD in the SUMMIT Study Lung Cancer Screening Cohort using Symptoms and Spirometry.

Sophie Tisi, Jennifer L Dickson, Carolyn Horst, et al

呼吁肺癌筛查关注慢阻肺：高危人群应同时检查肺功能!

European Respiratory Journal. 2022 Jul 26; PMID: 35896209

Green and blue spaces and lung function in the Generation XXI cohort: a life course approach.

Diogo Queiroz Almeida, Inês Paciência, Carla Moreira, et al

American Journal of Respiratory and Critical Care Medicine. 2022 Aug 2; PMID: 35916652

Care Quality for Patients with Chronic Obstructive Pulmonary Disease in the Readmission Penalty Era.

Juan C Rojas, Sukarn Chokkara, Mengqi Zhu, Peter K Lindenauer, Valerie G Press