Lancet Respiratory Medicine. 2022 Jan 10; PMID:35026180

        Stefan Andreas, Marco Testa, Laurent Boyer, et al

        Non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial.

        2017年时曾动念研发流感嗜血杆菌疫苗用于预防急性加重，看来此路不太走的通了。慢阻肺下呼吸道微生态变化中最明显的就是非分型流感嗜血杆菌负荷增加，而且它和AECOPD之间的关系也得到了验证，但是要加以有效干预还没有好办法。非分型流感嗜血杆菌的疫苗研发本身难度很大，看来得从其他路子想办法。

        JAMA. 2022 Jan 11; 327 (2) : 151-160. PMID:35015039

        Trishul Siddharthan, Suzanne L Pollard, Shumonta A Quaderi, et al

        Discriminative Accuracy of Chronic ObstructivePulmonary Disease Screening Instruments in 3 Low- and Middle-Income CountrySettings.

        这项研究表明，简单的筛查工具(问卷+PEF)在低资源地区是可行的。有必要开展进一步研究以明确筛查是否能够改善临床结局。

        European Respiratory Journal. 2021 Dec 16; PMID: 34916262

        Niroop Kaza, Vivian Y Lin, Denise Stanford, et al

        Evaluation of a novel CFTR potentiator in COPD ferrets with acquired cftr dysfunction.

        European Respiratory Journal. 2022 Jan 7; PMID:34996830

        A Diaz, Garry R Cutting, Michael H Cho, et al

        CFTR variants are associated with chronic bronchitis in smokers.

        European Respiratory Journal. 2022 Jan 7; PMID: 34996832

        Jenna McNeill, Ariel Chernofsky, Matthew Nayor, et al

        The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community.

        Chest. 2021 Dec 13; PMID: 34914976

        Shuen Yee Lee, Ma Shwe Zin Nyunt, Qi Gao, et al

        Co-occurrence of Physical Frailty and Chronic Obstructive Pulmonary Disease and Association with Disability and Mortality: Singapore Longitudinal Ageing Study.

        Chest. 2022 Jan 10; PMID:35026297

        Anouk W Vaes, Martijn A Spruit, Eleonore H Koolen, et al

        "Can do, do do" quadrants and 6-year all-cause mortality in patients with COPD.