Thorax. 2021 Nov 26;

        Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease.

        Safa Ahmadian, Don D Sin, Larry Lynd, et al

        PMID:34836921

        本文的价值在于介绍了一种方法来评价某干预措施对于某个患病整体的获益风险比，对于政策制定是非常有力的数据。值得注意的是在临床患者的治疗决策中仍应强调个体化，特别是应评估下呼吸道NTM定植/感染的可能性。

        应用大环内酯类药物预防慢阻肺急性加重的利弊之辩

        American Journal of Respiratory and Critical Care Medicine. 2021 Nov23;

        Long-term Ozone Exposure and Small Airways Dysfunction: The China Pulmonary Health (CPH) Study.

        Yue Niu, Ting Yang, Xiaoying Gu, et al

        PMID:34813411

        中国肺健康研究的又一项重要结果，围观点赞图片

        Chest. 2021 Nov 18;

        Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in Chronic Obstructive Pulmonary Disease.

        Charles R Esther, Wanda K O'Neal, Wayne H Anderson, et al

        PMID:34801592

        Thorax. 2021 Dec 1;

        Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies.

        Katarina Kamenar, Shakir Hossen, Akshay N Gupte, et al

        PMID:34853154

        JAMA. 2021 Dec 14; 326 (22) : 2287-2298.

        Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults.

        Emily S Wan, Pallavi Balte, Joseph E Schwartz, et al

        PMID:34905031

        European Respiratory Journal. 2021 Nov 18;

        Tiotropium treatment for bronchiectasis: a randomised, placebo-controlled, crossover trial.

        Lata Jayaram, Alain C Vandal, Catherina Chang, et al

        PMID:34795034

        噻托溴铵能显著改善肺功能，但未能改善AE发生率，对生活质量和活动能力也没有看到积极作用。这是目前为数不多的支扩剂用于有气流受限的支扩患者的研究，看起来并没有给我们带来惊喜。