Intercellular adhesion molecule 1 and progression of percent emphysema: The MESA Lung Study

Carrie P. Aaron， Joseph E. Schwartz， Suzette J. Bielinski， Eric A. Hoffman， John H.M. Austin， Elizabeth C. Oelsner， Kathleen M. Donohue， Ravi Kalhan， Cecilia Berardi， Joel D. Kaufman， David R. Jacobs Jr.， Russell P. Tracy， R. Graham Barre

Background

Endothelial intercellular adhesion molecule (ICAM) 1 binds neutrophils and facilitates their transmigration into the lung; E-selectin facilitates leukocyte rolling. As neutrophils contribute to tissue destruction in emphysema and chronic obstructive pulmonary disease, we hypothesized that soluble ICAM-1 (sICAM-1) and E-selectin (sE-selectin) would be associated with longitudinal progression of emphysema and lung function decline.

Methods

The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45–84 years old without clinical cardiovascular disease in 2000–02. The MESA Lung Study assessed percent emphysema (<−950 Hounsfield units) on cardiac (2000–07) and full-lung CT scans (2010–12), and spirometry was assessed twice over five years. sICAM-1 and sE-selectin were measured at baseline. Mixed-effect models adjusted for demographics, anthropometry, smoking, C-reactive protein, sphingomyelin and scanner factors.

Results

Among 1865 MESA Lung participants with measurement of sICAM-1 and percent emphysema the mean log-sICAM-1 was 5.5 ± 0.3 ng/mL and percent emphysema increased 0.73 percentage points (95% CI: 0.34, 1.12; P < 0.001) over ten years. A one SD increase in sICAM-1 was associated with an accelerated increase in percent emphysema of 0.23 percentage points over ten years (95% CI: 0.06, 0.39; P = 0.007). No significant association was found for sE-selectin, or between any adhesion molecule and lung function.

Conclusions

Higher levels of sICAM-1 were independently associated with progression of percent emphysema in a general population sample.

respiratory medicine

February 2015Volume 109, Issue 2, Pages 255–264

DOI: http://dx.doi.org/10.1016/j.rmed.2014.10.004 |