一项新研究显示，在生育治疗失败后，那些难以接受不育事实的女性的长期心理健康状态，会比那些放弃生育幻想的女性更差。

全球顶尖生殖医学期刊Human Reproduction在线公布了一项研究。研究首次对一大批女性(超过7000人)进行调查,试图探索在生育治疗失败后十年多时间内可能影响女性心理健康的不同因素。 这些因素包括是否已生育子女、是否仍希望继续孕育子女、诊断和医疗情况。

该研究的第一作者Sofia Gameiro博士表示：“我们已经知道经过生育治疗仍旧不育的女性会比通过治疗成功受孕的女性拥有更差的心理健康状态。然而，之前的大多数研究都是假定这只与是否育有子女有关，并没有考虑其他因素的影响。”

原文标题：Do children make you happier? Sustained child-wish and mental health in women 11–17 years after fertility treatment

原文链接：http://humrep.oxfordjournals.org/content/early/2014/08/17/humrep.deu178.full

作者：Sofia Gameiro、Alexandra W. van den Belt-Dusebout、Eveline Bleiker、Didi Braat、Flora E. van Leeuwen、Christianne M. Verhaak

Abstract

STUDY QUESTION Are fertility treatment-related factors, parenthood status and sustained child-wish associated with women's long-term mental health?

SUMMARY ANSWER Sustaining a child-wish is more strongly associated with women's long-term mental health than fertility treatment-related factors and parenthood status.

WHAT IS KNOWN ALREADY About one-third of the couples starting fertility treatment do not achieve parenthood and have to adjust to an unfulfilled child-wish. In women, remaining childless after treatment is associated with less favourable mental health. It is unclear if this is only related to their childlessness or if adjustment after unsuccessful treatment is affected by other variables. These include diagnostic and treatment-related factors (cause of fertility problems, age at first consultation, type and number of treatments) and the psychological ability to come to terms with the unfulfilled child-wish. Differentiating the relative contribution of these factors to women's long-term mental health will provide useful knowledge to support patients adjusting to negative treatment outcomes.

STUDY DESIGN, SIZE, DURATION A cross-sectional study with a nationally representative sample of 7148 women who started fertility treatment at any of the 12 IVF hospitals in the Netherlands from 1995 through 2000. Of 16 482 women who were invited to participate, 7148 (43.4%) provided psychological data.

PARTICIPANTS/MATERIALS, SETTING, METHODS The average age of women was 47 years and the average age at first fertility consultation was 30 years. Fifty-one per cent of women did IUI and 85% did IVF/ICSI. Ninety per cent of women were married/cohabiting, 20.9% remained childless and 5.9% had a child-wish. Women completed a questionnaire assessing diagnostic and treatment factors (retrospective data), parenthood status, sustained child-wish and mental health.

MAIN RESULTS AND THE ROLE OF CHANCE A multiple regression analysis controlling for background variables showed that, first, male factor (P < 0.05) and/or idiopathic infertility (P < 0.001) were associated with better mental health. Secondly, starting fertility treatment at an older age was associated with better mental health (P < 0.01). Thirdly, the interaction between parenthood status and sustained child-wish was significant (P < 0.01). Having a child-wish was associated with worse mental health for women with (β = −0.058, P < 0.01) and without children (β =−0.136, P < 0.001), but associations were stronger for the latter. Predictive factors accounted for <5% of the variation in mental health status in the study population.

LIMITATIONS, REASONS FOR CAUTION The sample was large and nationally representative. Response rate was in line with other studies but women without psychological data were less likely to have biological children and 15.9% of non-responders considered the questionnaire to be too confronting or to elicit too emotional memories. This could reflect an underestimation of the proportion of women with a sustained child-wish.

WIDER IMPLICATIONS OF THE FINDINGS Sustaining a child-wish is a more important risk for long-term adjustment problems than parenthood status. Women adjust better when they start treatment at older ages and know they were not responsible for the cause of the fertility problem. Fertility staff can play an important role in preparing patients for the possibility of treatment failure and the associated grief process. They can also inform patients about the positive effect of refocusing their life goals.

STUDY FUNDING/COMPETING INTEREST(S) This study was supported by a grant from the Dutch Cancer Society (2006-3631). No competing interests exist.