Rheumatology今日在线发布了一项新研究：统计显示，服用非甾体抗炎药（NSAID）的患者患上静脉血栓栓塞（包括深静脉血栓栓塞和肺栓塞）的风险显著提高。鉴于目前普通民众盛行服用非甾体抗炎药的情况，这一研究对公共卫生具有相当重要的影响。

原文标题：Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis

原文链接：http://rheumatology.oxfordjournals.org/content/early/2014/09/22/rheumatology.keu408.full

作者：Patompong Ungprasert、Narat Srivali、Karn Wijarnpreecha、Prangthip Charoenpong、Eric L. Knight

Abstract

Objective. The aim of this study was to integrate and examine the association between NSAID use and venous thromboembolism (VTE).

Methods. We conducted a systematic review and meta-analysis of studies that reported odds ratios, relative risks, hazard ratios or standardized incidence ratios for VTE among NSAID users compared with non-users. Pooled risk ratios and 95% CIs were calculated using a random effects generic inverse variance model.

Results. Six studies with 21 401 VTE events were identified and included in the data analysis. The pooled risk ratio of VTE in NSAID users was 1.80 (95% CI 1.28, 2.52).

Conclusion. Our study demonstrated a statistically significant increased risk of VTE among NSAID users. This finding has important public health implications given the prevalence of NSAID use in the general population.