膀胱肌肉低振幅有节律收缩：兔子模型
作者：Michael D. Byrne, Adam P. Klausner, John E. Speich, Jordan B. Southern, et al. 来源：Journal of Urology 日期：2013-03-12
导读
Fourier transform analysis of rabbit detrusor autonomous contractions reveals length-dependent increases in tone and slow wave development at long lengths
Abstract
Introduction
Bladder wall muscle (detrusor) develops low amplitude rhythmic contractions (LARC). The activity of LARC is increased in detrusor from patients with overactive bladder. In this in vitro study, we used Fast Fourier Transforms (FFT) to assess the length-dependency of LARC components
Materials & Methods
Strips of rabbit detrusor were placed in a muscle bath between two clips to adjust length and record isometric tension. Tissues stretched from 70% to 130% of a reference muscle length (Lref) at 10% increments were allowed to develop LARC at each length for 20 min. LARC data were analyzed using FFT and represented by a frequency rather than time spectrum.
Results
Based on FFT analyses summarized by signal peaks within specific frequency ranges, rabbit LARC waveforms were divided into 1 tonic and 2 phasic components defined as A0+A1F1+A2F2. A0 is a length-dependent basal tonic component that increases linearly. A1F1 is a fast wave with a length-dependent specific amplitude (A1) and length-independent constant frequency (F1) of ~0.2 Hz, and A2F2 is a slow wave with a length-dependent amplitude (A2) and frequency (F2).
Conclusions
FFT analysis revealed that rabbit LARC consists of a basal tonic component plus 2 phasic components. The amplitudes of all 3 components were length-dependent. The frequency of the fast component was not length dependent, and the slow component was absent at short muscle lengths, developing only at muscle lengths beyond that producing a maximum active contraction.
http://www.jurology.com/article/S0022-5347(13)00347-9/abstract
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