果蝇或成为尿石症研究转化模式生物
作者：Joe Miller, Thomas Chi, Pankaj Kapahi, Arnold J. Kahn, et al. 来源：Journal of Urology 日期：2013-03-12
导读
Drosophila Melanogaster as an Emerging Translational Model of Human Nephrolithiasis
Abstract
Purpose
The limitations imposed by human clinical studies and mammalian models of nephrolithiasis have hampered the development of effective medical treatments and preventative measures for decades. The simple but elegant Drosophila melanogaster is emerging as a powerful translational model of human disease, including nephrolithiasis and may provide important information essential to our understanding of stone formation. We present the current state of research using D. melanogaster as a model of human nephrolithiasis.
Materials and Methods
A comprehensive review of the English language literature was performed using PUBMED. When necessary, authoritative texts on relevant subtopics were consulted.
Results
The genetic composition, anatomic structure and physiologic function of Drosophila Malpighian tubules are remarkably similar to those of the human nephron. The direct effects of dietary manipulation, environmental alteration, and genetic variation on stone formation can be observed and quantified in a matter of days. Several Drosophila models of human nephrolithiasis, including genetically linked and environmentally induced stones, have been developed. A model of calcium oxalate stone formation is among the most recent fly models of human nephrolithiasis.
Conclusions
The ability to readily manipulate and quantify stone formation in D. melanogaster models of human nephrolithiasis presents the urologic community with a unique opportunity to increase our understanding of this enigmatic disease.
http://www.jurology.com/article/S0022-5347(13)03645-8/abstract
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