饮食摄入钠及果糖与尿路结石的关联：小鼠模型
作者：Sherry S. Ross, Elizabeth M. Masko, Michael R. Abern, Emma H. Allott, et al. 来源：Journal of Urology 日期：2013-03-12
导读
The Effect Of Dietary Sodium And Fructose Intake On Urine And Serum Parameters Of Stone
Abstract
Purpose
Dietary factors have been shown to play a role in stone disease in adults, but little is known about the relationship in children. We tested whether diet could alter urine and serum parameters in a pediatric mouse model.
Materials and Methods
30 BALB/c female mice (age 3 weeks) were randomized to mouse chow, a complex-carbohydrate Western diet (WD) or a high-fructose high- sodium (HFHS) Western diet. Body weights were measured twice weekly. Urine was periodically collected and mice were harvested on Day 30. Samples were pooled for analysis of serum and urine electrolytes factors.
Results
There were no significant differences in body weights among groups at any time nor in kidney weights at the time of sacrifice (all p>0.15). There were no observable increases in stone-forming analytes in the urine across the arms, with the exception of uric acid which tended to be higher in the WD and HFFS groups. There was a substantial decrease in urinary stone-inhibitors (magnesium and citrate), a decrease in urinary potassium and an increase in serum calcium in both Western diet groups. (This appeared to be more pronounced in the HFHS.-deleted)
Conclusions
This pilot study suggests that consumption of a Western diet, especially one composed of high fructose and sodium, may alter parameters that predispose to stone formation in children by reducing stone inhibitors. These results require validation in larger studies and ultimately in humans.
http://www.jurology.com/article/S0022-5347(13)03531-3/abstract
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