小鼠出生0-21天性别分化情况
作者：Bruce J. Schlomer, Max Feretti, Esequiel Rodriguez, Sarah Blaschko, et al. 来源：Journal of Urology 日期：2013-03-12
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关键字：
性别分化
Sexual differentiation in the male and female mouse from day 0 to 21: a detailed and novel morphometric description
Abstract
Purpose
The hypothesis of this study is that a significant portion of sexual differentiation of mouse external genitalia (ExG) occurs postnatally. To establish a baseline of normal development for which genital abnormalities can be compared, morphometric measurements and morphological descriptions of the postnatal period of sexual differentiation were determined in mice from birth to 21 days postnatal.
Methods
The ExG of male and female CD-1 mice wereserially sectioned for histologic staining. Age groups of 0-1, 2-3, 4-5, 10, and 21 day mice were studied. Three-dimensional reconstructions (3DR) were created to visually compare differences. Morphometric measurements of the distal ExG were performed and compared across age groups andbetween male and female.
Results
Morphologies of male and female mouse ExG are similar at 0-1 days but undergo dramatic changes over 21 days. Changes include the development of mesenchymal extensions that in males form the male urogenital mating protuberance (MUMP) and erectile bodies as well as comparable structures in females. Differences in morphometric measurements of homologous male and female become pronounced over 0 - 21 days and serve as a baseline for recognizing the genesis of malformations of the ExG.
Conclusion
Male and female mouse ExG are similar morphologically and morphometrically at birth but achieve dramatic differences by 21 dayssuggesting that a significant portion of sexual differentiation in the mouse occurs after birth. We described these changes using novel and accurate morphometric measurements and 3DRs.These results will be useful in studying abnormal sexual development of the mouse ExG.
http://www.jurology.com/article/S0022-5347(13)03530-1/abstract
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