中国马兜铃酸与CKD：中国横断面研究
作者：Jian Zhang, Luxia Zhang, Wenke Wang, Haiyan Wang, et al. 来源：AJKD 日期：2013-03-12
导读
Association Between Aristolochic Acid and CKD: A Cross-sectional Survey in China
Background
Long-term intake of herbs containing aristolochic acid (AA) has been reported to be associated with increased risk of chronic kidney disease (CKD), whereas population-based studies are limited.
Study Design
Cross-sectional study.
Setting & Participants
A national representative sample of 47,204 adults in China.
Predictor
Self-reported long-term use of medications containing AA.
Outcomes & Measurements
CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 and/or the presence of albuminuria, defined as albumin-creatinine ratio >30 mg/g.
Results
467 participants reported long-term AA intake, with a prevalence adjusting for a synthesized weight of 1.5% (95% CI, 1.2%-1.7%). After adjusting for age, sex, and other potential confounders, long-term AA intake was associated with eGFR <60 mL/min/1.73 m2 and albuminuria, with ORs of 1.83 (95% CI, 1.22-2.74) and 1.39 (95% CI, 1.03-1.87), respectively. Further adjustment for intake of nonsteroidal anti-inflammatory drugs did not change ORs substantially. A positive association between accumulated time of AA intake and kidney disease also was observed, with fully adjusted ORs of 1.07 (95% CI, 1.03-1.12) per 6-month longer intake for eGFR <60 mL/min/1.73 m2 and 1.04 (95% CI, 1.01-1.08) per 6-month longer intake for albuminuria.
Limitations
Self-reported intake of herbs containing AA; the AA content of the preparations by weight was unknown; single measurement of indicators of kidney damage.
Conclusions
Long-term intake of medications containing AA is prevalent in China and is associated with the presence of CKD.
http://www.ajkd.org/article/S0272-6386(13)00032-2/abstract
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