肾性指标评估急性肾损伤：小鼠肝移植模型
作者：Hai-Ying Kong, Fen Chen, Yong He, Lin-Jiao Wu, Li-Qing Wang, Sheng-Mei Zhu and Shu-Sen Zheng 来源：BMC Nephrology 日期：2013-03-12
导读
Intrarenal resistance index for the assessment of acute renal injury in a rat liver transplantation model
Background
Acute kidney injury (AKI) is a common complication after liver transplantation (LT) and associated with a high mortality. The renal resistive index (RI) is used to assess early renal function impairment in critical care patients. However, limited data are available concerning changes of renal RI and the development of AKI early after reperfusion. We approached to investigate the changes of renal RI and AKI after reperfusion in a rat liver transplantation model.
Methods
Rats were randomly divided into sham group or LT group. Ten rats in each group were used for the hemodynamic study and twenty for Doppler measurements during the procedure. Ten rats were sacrificed 30 min or 2 h after the reperfusion. We harvested kidneys, serum and urine for further analysis of the renal function.
Results
The intrarenal RI increased significantly in the anhepatic stage and decreased significantly after the reperfusion in the LT group compared with sham group (P < 0.05). AKI was seen after the reperfusion in the LT group. No correlation was noted between the RI and renal function parameters 30 min after reperfusion.
Conclusions
The intrarenal RI increased significantly during the anhepatic stage, and decreased significantly early after the reperfusion. Intrarenal RI was unable to assess renal function in a rat liver transplantation model.
http://www.biomedcentral.com/1471-2369/14/55/abstract
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