肾内科

转移性肾细胞癌405例术前活检与术后病理比较

作者:M. Pilar Laguna 来源:Journal of Urology 日期:2013-02-25
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关键字:  肾细胞癌 | 活检 | 病理 

 

Limitations of Preoperative Biopsy in Patients with Metastatic Renal Cell Carcinoma: Comparison to Surgical Pathology in 405 Cases
 
 
 
Abstract 
 
Objective
To evaluate the ability of preoperative biopsy to identify high-risk pathological features by comparing pathology from preoperative metastatic site and primary tumour biopsies with nephrectomy pathology in patients with metastatic renal cell carcinoma (mRCC).
 
Patients and Methods
We reviewed clinical and pathological data from patients who underwent biopsy before cytoreductive nephrectomy for mRCC at MD Anderson Cancer Center (MDACC) from 1991 to 2007. Percutaneous biopsy techniques included fine-needle aspiration, core needle biopsy or a combination of both techniques.
 
Results
The pathology of 405 preoperative biopsies (239 metastatic site, 166 primary tumour) from 378 patients was reviewed at MDACC before cytoreductive nephrectomy. The biopsy and nephrectomy specimens had the same histological subtype in 96.0% of clear-cell renal cell carcinomas (RCCs) and 72.7% of non-clear-cell RCCs. Of 76 nephrectomy specimens where sarcomatoid de-differentiation was identified, only seven (9.2%) were able to be identified from the preoperative biopsy. In 38.3% of patients, the same Fuhrman grade was identified in both the biopsy and nephrectomy specimens. A definitive diagnosis of RCC was more likely to be reported in primary tumour biopsies than in metastatic site biopsies (P < 0.001).
 
Conclusions
Preoperative biopsy has limited ability to identify non-clear-cell histological subtype, Fuhrman grade or sarcomatoid features. When surgical pathology is not available, a biopsy obtaining multiple samples from different sites within the primary tumour should be recommended rather than limited metastatic site biopsy to identify patients for clinical trials.
 
 
 
 
http://www.jurology.com/article/S0022-5347(13)00359-5/abstract
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