伊马替尼用于治疗免疫介导的肾损伤
作者：Eric Wallace and Leslie Gewin 来源：AJKD 日期：2013-02-22
导读
Imatinib: Novel Treatment of Immune-Mediated Kidney Injury
Abstract
The treatments for many autoimmune diseases are limited in efficacy, and long-term use is associated with severe adverse events. The tyrosine kinase inhibitors have proven to be well tolerated for long treatment periods, with minimal adverse events, in the oncology population. These agents have recently been used to treat autoimmune diseases. We review the potential mechanisms whereby tyrosine kinase inhibitors may modulate the immune response and inhibit fibrogenesis and discuss the current evidence for their use in the treatment of autoimmune diseases of the kidney.
http://jasn.asnjournals.org/content/early/2013/02/20/ASN.2012080818.abstract
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