近日，来自爱丁堡大学的研究人员通过研究表示，遭受焦虑或抑郁或许会增加个体因患肝脏疾病死亡的风险，相关研究发表于国际杂志Gastroenterology上，该研究首次揭示了高水平的心理压力和因肝脏疾病引发的死亡之间的可能性关联。

　　目前研究人员并不清楚心理压力和肝脏疾病之间的生物关联，此前有研究表明心理压力会使个体患心血管疾病的风险增加。同时心血管疾病的风险因子，比如肥胖和血压升高，也和常见形式的肝脏疾病直接相关，如非酒精性脂肪肝等。

　　类似地，经历抑郁和焦虑或许和间接和肝脏疾病引发的死亡相关；文章中，研究人员就对超过16.5万存在心理压力的个体进行了调查问卷形式的研究，同时也对个体的反应进行了分析，随后研究者对患者的疾病进展追踪了超过10年时间，同时对患者的死亡及死亡原因进行了记录。

　　研究者表示，心理压力症状得分值较高的个体相比得分低的个体往往更易于因肝脏疾病引发死亡，该研究同时也考虑了其它因素，比如酒精消耗、肥胖、188bet在线平台网址 及社会经济地位等。本文研究为后期阐明思想和身体的重要关联提供了新的证据，同时也表明心理压力对个体的损伤效应或许会对身体健康有害；但目前研究人员并不能确定两者之间的因果关系，需要后期继续进行深入的研究才能够解释。

　　doi:10.1053/j.gastro.2015.02.004

　　PMC:

　　PMID:

　　Association Between Psychological Distress and Liver Disease Mortality: A Meta-analysis of Individual Study Participants

　　Tom C. Russcorrespondenceemail, Mika Kivimki, Joanne R. Morling, John M. Starr, Emmanuel Stamatakis, G. David Batty

　　Background &Aims Risk factors for cardiovascular disease, such as obesity and hypertension, have been associated with nonalcoholic fatty liver disease. Psychological distress (symptoms of anxiety and depression) is a risk factor for cardiovascular disease, so it might also be associated, directly or indirectly, with liver disease. We investigated the relationship between psychological distress (measured by the 12-item General Health Questionnaire [GHQ]) and liver disease mortality. Methods We performed a meta-analysis of data from individual participants in 16 prospective studies of the general population in the United Kingdom, initiated from 1994 through 2008. Subjects were assigned to groups based on GHQ score: 0 (no distress), 1 3, 4 6, or 7 12. Results We analyzed data from 166,631 individuals (55% women; mean ± SD age, 46.6 ± 18.4 years; range, 16 102 years). During a mean follow-up period of 9.5 years, 17,368 participants died (457 with liver disease). We found a significant increase in liver disease mortality with increase in GHQ score (Ptrend <.001). The age- and sex-adjusted hazard ratio for the highest GHQ score category (ie, 7 12), compared with the 0 score category, was 3.48 (95% confidence interval: 2.68 4.52). After adjustment for health behaviors, socioeconomic status, body mass index, and diabetes, this hazard ratio decreased to 2.59 (95% confidence interval: 1.82 3.68). Conclusions Based on a meta-analysis, psychological distress is associated with liver disease mortality, although this finding requires additional analysis. Although one is not likely to cause the other, we provide additional evidence for the deleterious effects of psychological problems on physical health.