如果你仔细观察一下你吃得东西，再认真想想，你就会发现这些东西对机体的胆固醇水平、血压、血糖并没有带来任何改善，那么该怎么办呢？近日，一项发表在The FASEB Journal杂志上的研究论文中，来自奥克兰儿童医院的研究人员通过研究表示，维生素和矿物质缺失所有发的炎症或许是罪魁祸首，在某些个体中，当营养物的缺失及时纠正后，其机体的健康标志物就会得到明显改善。

　　研究者Bruce Ames博士说道，我们都知道糟糕的饮食习惯会增加疾病风险，但很显然这并不是一个足够信服的理由来督促我们改善饮食习惯；然而一种相对容易的干预措施比如一块营养棒或许会帮助人们意识到每天食物中足够的营养对机体的正向影响。

　　文章中研究者进行了三项临床试验，他们让成年个体每天食用两块营养棒，持续2个月，参与者以自身作为对照，随后研究者在两个月的时间段内对每一位个体进行研究，测定并记录个体机体的生化指标和物理性指标，生化指标比如胰岛素、低密度脂蛋白水平和高密度脂蛋白水平，物理性指标比如血压和体重等。

　　过重或肥胖个体更应该倾向于健康的代谢饮食方式，某些个体可能会通过少食、低热量等方式来控制降低体重。最后杂志主编Gerald Weissmann博士说道，如果变得健康就好象减肥或保持身材那样简单，那么生活在极其缺乏食物环境下的祖先或许会与我们同在。这项研究阐明了我们所吃食物的重要性，这对于维持机体健康，抵御疾病的风险或将非常重要。

　　doi:10.1096/fj.15-271833

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　　A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.

　　Joyce C. McCann*,1, Mark K. Shigenaga*,1, Michele L. Mietus-Snyder*, , Ashutosh Lal*, Jung H. Suh*, Ronald M. Krauss*, Ginny L. Gildengorin*, Alisa M. Goldrich*, Devan S. Block*, Swapna V. Shenvi*, Tara H. McHugh , Don A. Olson and Bruce N. Ames*

　　This study determined if twice-daily consumption of a nutrient-dense bar intended to fill gaps in Western diets, without other dietary/lifestyle requirements, favorably shifted metabolic/anthropometric indicators of dysregulation in a healthy direction. Three 8-wk clinical trials in 43 healthy lean and overweight/obese (OW/OB) adults, who served as their own controls, were pooled for analysis. In less inflamed OW/OB [high-sensitivity C-reactive protein (hsCRP) <1.5], statistically significant decreases occurred in weight ( 1.1 ± 0.5 kg), waist circumference ( 3.1 ± 1.4 cm), diastolic blood pressure ( 4.1 ± 1.6 mmHg), heart rate [HR; 4.0 ± 1.7 beats per minute (bpm)], triglycerides ( 72 ± 38.2 mg/dl), insulin resistance (homeostatic model of insulin resistance) ( 0.72 ± 0.3), and insulin ( 2.8 ± 1.3 mU/L); an increase in HDL-2b (+303 ± 116 nM) and realignment of LDL lipid subfractions toward a less atherogenic profile [decreased small LDL IIIb ( 44 ± 23.5 nM), LDL IIIa ( 99 ± 43.7 nM), and increased large LDL I (+66 ± 28.0 nM)]. In the more inflamed OW/OB (hsCRP >1.5), inflammation was reduced at 2 wk ( 0.66 mg/L), and HR at 8 wk ( 3.4 ± 1.3 bpm). The large HDL subfraction (10.5–14.5 nm) increased at 8 wk (+346 ± 126 nM). Metabolic improvements were also observed in lean participants. Thus, favorable changes in measures of cardiovascular health, insulin resistance, inflammation, and obesity were initiated within 8 wk in the OW/OB by replacing deficiencies in Western diets without requiring other dietary or lifestyle modifications; chronic inflammation blunted most improvements.—McCann, J. C., Shigenaga, M. K., Mietus-Snyder, M. L., Lal, A., Suh, J. H., Krauss, R. M., Gildengorin, G. L., Goldrich, A. M., Block, D. S., Shenvi, S. V., McHugh, T. H., Olson, D. A., Ames, B. N. A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.