2012年10月28-31日，第54届美国放射肿瘤学会（ASTRO）年会在美国波士顿举行。来自世界各地的放射肿瘤学领域的医生及相关人士共计11000多人参会。本届年会的主题是“通过创新改善患者治疗（Advancing Patient Care through Innovation）”。 对本届年会进行了专题报道（http://zt.cmt.com.cn/zt/astro2012/index.html），敬请关注！

　　会上，日本学者报告了一项研究：Acute Cardiac Impairment Associated With Concurrent Chemoradiation Therapy for Esophageal Cancer ，其摘要如下：

Purpose/Objective(s)
To evaluate acute cardiac effects of concurrent chemoradiation therapy (CCRT) for esophageal cancer.

Materials/Methods
This prospective study was approved by the institutional review board and written informed consent was obtained from all participants. The left ventricular function (LVF) of 31 patients with esophageal cancer who received cisplatin and 5-fluorouracil-based CCRT was evaluated using cardiac cine magnetic resonance imaging. The patients were classified into two groups based on mean LV dose. The parameters related to LVF were compared between before and during (40 Gy) or between before and after CCRT using Wilcoxon matched-pairs single rank test and parameter ratios (during / before CCRT, after / before CCRT) were also compared between the groups with t-test. Data were expressed as mean ± standard error.

Results
In low LV-dose group (n = 10; mean LV dose <0.6 Gy), LV ejection fraction decreased significantly (before vs. during vs. after CCRT; 62.7 ± 2.98 vs. 59.8 ± 2.56 vs. 60.6 ± 3.89%, p < 0.05). In high LV-dose group (n = 21; mean LV dose of 3.6-41.2 Gy), LV end-diastolic volume index (before vs. after CCRT; 69.1 ± 2.93 vs. 57.0 ± 3.23 mL/m2), LV stroke volume index (38.6 ± 1.56 vs. 29.9 ± 1.60 mL/m2), and LV ejection fraction (56.9 ± 1.79 vs. 52.8 ± 1.15%) decreased significantly (p < 0.05) after CCRT. Heart rate increased significantly (before vs. during vs. after CCRT; 66.8 ± 3.05 vs. 72.4 ± 4.04 vs. 85.4 ± 3.75/min, p < 0.01). LV wall motion decreased significantly (p < 0.05) in segments 8 (before vs. during vs. after CCRT; 6.64 ± 0.54 vs. 4.78 ± 0.43 vs. 4.79 ± 0.50 mm), 9 (6.88 ± 0.45 vs. 5.04 ± 0.38 vs. 5.27 ± 0.47 mm), and 10 (9.22 ± 0.48 vs. 8.08 ± 0.34 vs. 8.19 ± 0.56 mm). The parameter ratios of LV end-diastolic volume index, stroke volume index, wall motion in segment 9, and heart rate showed significant difference (p < 0.05) after CCRT between the groups.

Conclusions
CCRT for esophageal cancer impairs LVF from an early treatment stage. This impairment is prominent in patients with high LV dose.