近日，根据8月28日在线发表在《Head &Neck》杂志上的一篇文章表明，研究发现幽门螺杆菌(H. pylori)感染可增加喉鳞状细胞癌的发生机率，但研究发现幽门螺杆菌(H. pylori)感染对鼻咽癌基本无影响。

　　中国复旦大学医学院Zhou Jian 博士和他的同事们对幽门螺杆菌的感染作用进行了一项系统回顾性相关研究，本次回顾性研究旨在研究有关咽喉癌患者中幽门螺杆菌的感染情况。通过一系列整理分析，本次分析所得数据一共来自11项相关研究的结果，最后，研究人员应用该数据进行了meta分析。

　　在本项研究中研究人员发现，在研究幽门螺杆菌感染的过程中，最终得出的实验结果发现，与正常对照组相比，实验组中幽门螺杆菌含量有明显升高迹象，(比值比为2.87；95%置信区间内1.71比4.84；P <0.0001)。喉鳞状细胞癌和鼻咽癌的比值比分别为3.28(95%置信区间，1.91比5.63；P <0.0001)和1.35(95%置信区间，0.86比2.12；P = 0.188)。

　　“这个meta分析结果有力的证明了有关幽门螺旋杆菌感染与咽喉癌之间存在联系，特别是通过聚合酶链反应(PCR)和酶联免疫吸附试验(ELISA)进行确证后。”作者写道。“然而，通过分析发现幽门螺旋杆菌感染和鼻咽癌之间没有发现明显的关联迹象。此外，少量参与这项研究的项目在这个评估中引起了较大的置信区间。”

　　doi:10.1002/hed.24214

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　　Association between helicobacter pylori infection and carcinoma of the larynx or pharynx

　　Jian Zhou PhD, Duo Zhang PhD, Yue Yang MD, Liang Zhou PhD andLei Tao PhD*

　　Background Infection with Helicobacter pylori (H. pylori) plays a role in the development of gastric carcinoma. However, there is controversy as to whether H. pylori infection increases laryngeal or pharyngeal cancers. Methods We managed a systematic review of researches related to H. pylori infection in laryngeal or pharyngeal carcinomas, distributed up to December 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by random effects models or according to heterogeneity I2. Results Eleven studies were involved in the meta-analysis. Overall, H. pylori infection was significantly higher in the study group compared with the normal control group (OR = 2.87; 95% CI = 1.71–4.84; I2 = 67.1; p <.0001, random effects analysis). The ORs for laryngeal carcinoma were 3.28 (95% CI = 1.91–5.63; I2 = 58; p <.0001, random effects model). The ORs for pharyngeal cancer were 1.35 (95% CI = 0.86–2.12; p = .188, random effects model). Conclusion This study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital-based control group and diagnosed by polymerase chain reaction (PCR) or enzyme-linked immunosorbent assay (ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. 2015 Wiley Periodicals, Inc. Head Neck, 2015