中药产品和肝脏：副作用及其机制的综述
Herbal Products and the Liver: A Review of Adverse Effects andMechanisms Leonard B. Seeff ,Herbert L. Bonkovsky,Victor J. Navarro,Guqi Wang Herbal products have been used for centuries among indigen
Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms
Leonard B. Seeff , Herbert L. Bonkovsky, Victor J. Navarro, Guqi Wang
Herbal products have been used for centuries among indigenous people to treat symptoms and illnesses. Recently, their use in Western countries has grown significantly, rivaling that of prescription medications. Currently, herbal products are used mainly for weight loss and bodybuilding purposes but also to improve well-being and symptoms of chronic diseases. Many people believe that because they are natural, they must be effective and safe; however, these beliefs are erroneous. Few herbal products have been studied in well-designed controlled trials of patients with liver or other diseases, despite testimony to the contrary. Moreover, current highly effective antiviral drugs make efforts to treat hepatitis C with herbal products redundant. Herbal products are no safer than conventional drugs and have caused liver injury severe enough to require transplantation or cause death. Furthermore, their efficacy, safety, and claims are not assessed by regulatory agencies, and there is uncertainty about their reported and unreported contents. We review the history of commonly used herbal products, as well as their purported efficacies and mechanisms and their adverse effects.
March 2015Volume 148, Issue 3, Pages 517–532.e3
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