[ADA2015]中国代谢综合征患者：男性患188bet在线平台网址 风险高于女性
北京中日医院杨文英教授团队的一项研究摘要2015年第75届美国188bet在线平台网址 协会(ADA)科学年会上发布。该研究调查了中国代谢综合征患者中性别差异与188bet在线平台网址 发病率之间的相关性。以下是研究摘要译文。
北京中日医院杨文英教授团队的一项研究摘要2015年第75届美国188bet在线平台网址 协会(ADA)科学年会上发布。该研究调查了中国代谢综合征患者中性别差异与188bet在线平台网址 发病率之间的相关性。以下是研究摘要译文。
目的：既往研究已观察到中国人群的188bet在线平台网址 发病率具有性别差异，但在代谢综合征人群中188bet在线平台网址 发病率是否具有性别差异尚不清楚。
方法：研究人员前瞻性调查了159例男性、301例女性代谢综合征患者中性别差异与188bet在线平台网址 发病率之间的相关性。采用Cox比例风险回归模型对相关性进行评估。
结果：在平均随访2.5年后，共有15例患者出现188bet在线平台网址 ，其中9例男性、6例女性。校正基线时年龄、受教育程度、职业、治疗药物、腰围、血压、HbA1c、甘油三酯、低密度脂蛋白等多种混杂因素后，男性188bet在线平台网址 发病风险较女性增加了6.49倍(HR 6.49，95% CI 1.51-28.0)。甘油三酯水平每增加1 mmol/L，所有患者的的188bet在线平台网址 风险增加31.4%(95% CI 1.02-1.70)，其中男性患者188bet在线平台网址 风险增加65.0%(95% CI 1.12-2.43)，女性患者增加37.0%(95% CI 0.45-4.15)。
结论：该研究提示对于代谢综合征患者，男性的188bet在线平台网址 发病风险高于与女性。甘油三酯水平可能是导致男性代谢综合征患者188bet在线平台网址 风险增加的重要因素。
【研究摘要】
| Abstract Number: | 2716-PO |
| Title: |
Sex Differences in the Incidence of Diabetes Mellitus among Subjects with Metabolic Syndrome |
| Authors: |
WENHUI ZHAO, XIAOYAN XING, HAIQING ZHU, SHI BU, RUIFEN DENG, ZHAOQING LI, XUELI LIU, WENYING YANG, Beijing, China |
| Abstract: |
Background Sex differences in the prevalence of diabetes mellitus were observed in China. But whether there is difference between sexes in the incidence of diabetes mellitus did not describe before. Methods We prospectively investigated the association between sexes and incidence of diabetes mellitus among 159 male and 301 female subjects with metabolic syndrome. Cox proportional hazards regression models were used to estimate this association. Results During a mean follow-up of 2.5 years, 15 incident cases (9 in male, 6 in female) of diabetes mellitus were identified. The multivariable-adjusted (age, education, occupation, medicine treatment, waist circumference, blood pressure, HbA1c, triglyceride and low density lipoprotein cholesterol at baseline) hazard ratio (HR) for incidence of diabetes mellitus associated with sex was 6.49 (95% confidence interval [CI] 1.51-28.0). There was a 31.4% increase of the risk of diabetes mellitus with 1 mmol/l increase of triglyceride (95% CI 1.02-1.70) in all subjects, with 65.0% increase in male (95% CI 1.12-2.43) and 37.0% increase in female (95% CI 0.45-4.15), respectively. Conclusions The current study indicates the risk of diabetes mellitus is higher in male than female subjects with metabolic syndrome. Triglyceride may contribute to the high risk in male.
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