一项关于沙特女性卵巢上皮癌患者和肿瘤特征的详细研究

　　A Detailed Study of Patients and Tumor Characteristics of Epithelial Ovarian Cancer in Saudi Women

　　I. Al-Badawi¹, A. Munkarah², A. Tulbah³, S. Ahmad⁴

　　¹Ob/Gyn, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, ²Henry Ford, Detroit, MI, USA, ³King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, ⁴Florida Hospital Cancer Institute, Orlando, FL, USA

　　Background: The Saudi population is characterized by high parity and inter-marriages that may impact ovarian carcinogenesis. Herein, we analyzed the tumor characteristics and outcomes in Saudi patients with epithelial ovarian cancer (EOC).

　　Material and methods: EOC patients treated at King Faisal Specialist Hospital during 1995-2007 were identified retrospectively through review of the medical records. Patients/tumor characteristics were collected including: age at diagnosis, marital status, parity, histology, stage, treatment rendered, and follow-up data.

　　Results: 193 patients with EOC were identified in this cohort. Mean age was 55.1 years, body-mass index (BMI) was 27.2 kg/m². Median parity was 7.0. Only one patient reported family history of cancer (pancreatic cancer in father; 164 women reported negative family history; 27 were not available). Tumor distribution by FIGO stage was: 12 (6.2%) women stage I, 1 (0.5%) stage II, 130 (67.4%) stage III, 39 (20.2 %) stage IV disease, and 11 (5.7%) unknown. Information on residual disease was available on 98 patients only with optimal debulking (< 1 cm) completed on 61 patients. The median PFS from end of chemotherapy to recurrence/progression was 11.2 months (95% CI 8.8-14.3). Tumor histology, size of residual disease, and stage at diagnosis were significant prognostic factors. Age, BMI, tumor histology and grade had no impact on survival.

　　Conclusion: Patients presenting with advanced-stage disease is higher among Saudis than those reported in global literature. Despite high-intermarriage rates, reported family history for related cancers was quite low in this cohort. Notably, this is the first study evaluating at EOC in Saudi patients.

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