乳腺癌保乳手术后继发血管肉瘤：7例病例报告
乳腺癌保乳手术后继发血管肉瘤：7例病例报告Hemangiosarcoma after breast conserving therapy of breast cancer, report of seven cases Background: Hemangiosarcomas of the breast&nbs
Hemangiosarcoma after breast conserving therapy of breast cancer, report of seven cases
Background: Hemangiosarcomas of the breast represent a rare disease of the breast mainly occurring as secondary neoplasias with a latency of 5-10 years after primary treatment of breast cancer and are associated with an unfavourable prognosis. Radiation therapy, which is integrated within the concept of breast conserving therapy ranks as the main risk factor.
Patient and method: In this report we describe the clinical course of 7 patients including their molecular genetic pattern and give a summary of the actual literature.
Results: Haemangiosarcomas occur as a secondary neoplasm with a latency of 5-10 years after primary treatment of breast cancer and have an unfavorable prognosis. A genetic predisposition is assumed, but we could not find a significant role of tumor suppressor genes BRCA1, BRCA2 or p53 in our patients.
Conclusion: Due to limited available data for these tumours, recommendations for therapy include radical tumour resection achieving wide free margins and inconsistent regimens of chemo- and/or immune-therapy modalities. In the majority these are orientated on the systemic therapy -regimens for other cutaneous sarcomas, such as Kaposi's sarcoma. Efforts should be taken for a nationwide systematic registration of all cases of post-irradiation hemangiosarcomas.
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