10月13-16日，第14届国际妇科肿瘤学会双年会（IGCS 2012）在加拿大温哥华举行。IGCS 2012一如既往地为参会者奉上妇科肿瘤学领域最新研究进展，提供发布、讨论和争辩最新科学信息的良机。金宝搏网站登录技巧 对本届年会进行了专题报道（http://zt.cmt.com.cn/zt/igcs2012/index.html）。 

研究摘要：

AGenetically Engineered MouseModel forHigh-Grade
Serous ‘‘Ovarian’’ Carcinoma Arising in the Fallopian
Tube
R Perets1, KWMuto2, JG Bijron3, KT Chin2, BB Poole2, CP
Crum3, DM Dinulescu2*, R Drapkin1,3*
1Department of Medical Oncology, Center for Molecular
Oncologic Pathology, Dana-Farber Cancer Institute, Boston,
MA; 2Eugene Braunwald Research Center, Department of
Pathology, Brigham and Women’s Hospital, Harvard Medical
School, Boston, MA; 3Department of Pathology, Division of
Women’s and Perinatal Pathology, Brigham and Women’s
Hospital, Boston, MA.
* These authors contributed equally to this work.
Background: Ovarian cancer is the most lethal gynecologic
malignancy because most cases are detected in late stage, a
finding that has thwarted attempts to understand the pathogenesis
and cell of origin of this disease. The traditional view
of epithelial ovarian pathogenesis asserts that all tumor subtypes
share a common origin in the ovarian surface epithelium
(OSE). There is robust data to support the OSE as the site of
origin for many ovarian tumors, including low-grade carcinomas
and borderline tumors. However, the pathogenesis of
high-grade serous ovarian carcinoma, the most common type
of ovarian cancer, continued to defy explanation by the OSE
model. More recent studies suggested that the fallopian tube
epithelium, rather than the OSE, may be the site of origin for
most pelvic serous carcinomas (PSC, defined as ovarian,
peritoneal, and tubal high-grade serous carcinomas).
Methods and Results: We show here that the fallopian tube
epithelium can be the site of origin of PSC by genetically
engineering a mouse model that specifically targets the fallopian
tube secretory cell with defined genetic alterations that
are characteristic of human PSC. These mice developed tubal
intraepithelial serous carcinomas, a precursor to PSC, that
are morphologically and immunophenotypically similar to
the lesions described in human patients. Furthermore, these
intraepithelial lesions progress to widespread peritoneal disease
that recapitulates the presentation of high-grade PSC in women.
The tumors express common serous markers such as P53,
PAX8, and WT1. Tumor-bearing mice show high levels of the
best characterized serum marker of ovarian cancer, CA-125.
Conclusion: Taken together, our model is the first genetically
engineered mouse model that truly recapitulates human serous

carcinoma by means of pathogenesis, clinical characteristics,
immunophenotype, and serum biomarkers. Our model serves as
proof of concept that the fallopian tube epithelium can be the site
of origin of PSC.