Weijie Zeng

 　　1. State Key Laboratory of Cardiovascular Disease，Fuwai Hospital, National Center for Cardiovascular Diseases，Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

　　2. The Fisrt Affiliated Hospital of Jinan University, Guangzhou 510630, China

　　Background  Statins have been shown to both prevent and attenuate pulmonary hypertension in animal models. This study investigates the potential therapeutic benefits of atorvastatin as an affordable treatment for pulmonary hypertension patients.

　　Methods  Two hundred and twenty patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) were randomized, double-blind, to receive atrovastatin 10 mg daily or matching placebo in addition to supportive care.

　　Results  At 6 months, 6-minute walk distance decreased by 16.6m in the atorvastatin group and 14.1m in the placebo group. The mean placebo-corrected treatment effect was –2.5 m (95% confidence interval: -38 to 33; p=1.0), based on intention to treat. A small non-significant increase in pulmonary vascular resistance and fall in cardiac output was seen in both treatment groups. There was no significant difference in the proportion of patients who improved, remained stable or showed deterioration in WHO functional class between atorvastatin and placebo treatments. Nine patients died in the atorvastatin group and 11 in the placebo group. Serum cholesterol levels fell significantly on atorvastatin treatment. Discontinuation rates were 23.2% and 26.9% on atorvastatin and placebo respectively.

　　Conclusion  Atorvastatin 10 mg daily has no beneficial effect on the natural history of PAH or CTEPH over 6 months.