在欧洲心脏病学会（ESC）2012学术年会上，华西医院饶莉等发表报告《Evaluation the alteration of mitral valve structures in functional mitral regurgitation using real-time three-dimensional transesophageal echocardiography》，内容为实时三维超声心动图观察二尖瓣结构改变对功能性二尖瓣反流的影响。 

　　原文摘要：

　　Objective:To investigate the geometric alterations of the mitral leaflets (MV) and annulus (MA) using real-time three-dimensional transesophageal echocardiography (RT-3DTEE), and to clarify the effect of MV structures' changes in FMR occurrence.

　　Methods:Twenty-five patients with paroxysmal supraventricular tachycardia, 25 isolated paroxysmal atrial fibrillation patients and 20 old myocardial infarction patients without functional mitral regurgitation (FMR) were enrolled as controls, twenty ischemic cardiomyopathy cases with FMR were ICM group. Standard RT-3DTEE evaluations were performed. The quantification parameters include: anterior-posterior diameter (APD), anterolateral-posteromedial (ALPMD), three dimensional annulus circumference (3DAC), two dimensional annulus area (2DAA), three dimensional annulus area (3DAA), sphericity Index (SI), non-planar angle (NPA), two dimensional annulus area fraction (2DAAF); tenting volume (TV); tenting height (TH); commissural diameter (CD), anterior leaflet area (ALA), posterior leaflet area (PLA), tenting volume index (TVI), tenting volume fraction (TVF), coaptation index (CI) (Fig. 1)

　　Results:There were significant difference of APD, ALPMD, NPA, AC, 2DAA, 3DAA, TV, TH, CD, ALA, PLA, TVI, CI, AAF in different groups (F>3.84,P<0.05). Correlation analysis revealed significant negative correlations between left ventricular dimension, left atrial dimension, left ventricular ejection fraction and MA, MV parameters except for SI, TVF and NPA (p<0.05).

　　Conclusions:The geometric and function alteration of MA and MV not only the final way of FMR, but also make the FMR worsen. The application of a series of new quantitative parameters in this study, including NPA, TVI, CI, may helpful to make up the appropriate FMR therapeutic plans and assess the prognosis.