欧洲心脏病学会（ESC）2012年会中国专家报告摘编：广东省人民医院陈纪言教授报告《The relationship between hyperuricemia and the risk of contrast-induced acute kidney injury after percutaneous coronary intervention in patients with relatively normal serum creatinine》指出：PCI术后肌酐水平相对正常的患者，高尿酸血症与PCI造影剂所致急性肾损伤（CI-AKI）显著相关。

　　摘要原文：

　　Objectives: This study evaluated the predictive value of hyperuricemia for risk of CI-AKI in patients with relatively normal serum creatinine (SCr) who were undergoing percutaneous coronary intervention (PCI).

　　Methods and Results: A total of 788 patients with relatively normal baseline SCr (< 1.5 mg/dL) undergoing PCI were prospectively enrolled and divided into two groups (hyperuricemic group, n = 211, and normouricemic group, n = 577). CI-AKI occurred in 17 (8.1%) of the hyperuricemic group and 8 (1.4%) of the normouricemic group (P < 0.001). In-hospital mortality (2.4% vs. 0.3%, P = 0. 007) and the cumulative 1-year mortality (P = 0.067) were higher in the hyperuricemic group. Multivariate analysis, adjusting for potential confounding factors, resulted in an odds ratio for CI-AKI in the hyperuricemic group, as compared with the normouricemic group, of 5.38 (95% confidence interval, 1.99-14.58; P = 0.001).

　　Conclusion: Hyperuricemia was significantly associated with the risk of CI-AKI in patients with relatively normal SCr after PCI. This needs further prospective trials aimed at examining the effect of uric acid-lowering therapies for prevention of CI-AKI.