非甾体抗炎药会增加房颤患者严重出血风险
该观察性队列研究纳入150,000多例在1997-2011年入院的丹麦房颤(AF)患者，并审查了同时应用NSAIDs和抗血栓药物的严重出血和血栓栓塞风险。
该观察性队列研究纳入150,000多例在1997-2011年入院的丹麦房颤(AF)患者，并审查了同时应用NSAIDs和抗血栓药物的严重出血和血栓栓塞风险。3个月时，同时应用NSAIDs和抗血栓药物的患者与仅应用抗血栓药物的患者相比，严重出血的绝对风险差为每1000例患者发生1.9次事件。而对于仅应用口服抗血栓药物的患者，其绝对风险差为每1000例患者发生2.5次事件。
AF患者应用NSAIDs与严重出血或血栓栓塞风险升高相关。
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The authors of this observational cohort study of over 150,000 Danish patients with atrial fibrillation (AF) hospitalized from 1997 to 2011 examined the risk for serious bleeding and thromboembolism associated with NSAID and antithrombotic therapy. At 3 months, the absolute risk difference for serious bleeding in patients taking NSAIDs vs those not taking NSAIDs was 1.9 events per 1000 patients. The absolute risk difference in patients who received oral anticoagulant therapy was 2.5 events per 1000 patients.
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