调节T细胞的临床意义
Regulatory T Cells: Customizing for the Clinic
Xue-Hao Wang
Regulatory T cells (Tregs) play a dominant role in transplantation tolerance, as shown by adoptive cell transfer for the prevention of organ graft rejection and GVHD in experimental models. Translating Treg therapies to humans requires cell isolation and purification, because transfer of the accompanying effector T cells would exacerbate rather than ameliorate human disease. Immune-suppressive cellular immunotherapy requires large numbers of Treg and recent data have shown to conquer this barrier. Along with recent phase I clinical trial results provide a platform for clinical use of Treg cells as personalized therapeutic agents for the treatment of autoimmune diseases, graft-versus-host disease, and transplant rejection.
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