久坐与不良健康转归有关。既往研究主要是依赖自我报告数据，尚缺乏客观检测到的久坐时间与心脏代谢生物指标相关性的数据，尤其是在西班牙裔和拉丁裔美国人中。美国学者们近期在上述人群中开展了一项基于人群的相关研究，结果表明，久坐时间和心脏代谢生物指标间存在有害的关系，这种相关性独立于体力活动。研究结果强调了减少久坐时间对于预防心血管代谢性疾病的重要性，即使是在那些满足体力活动推荐量的人群中。相关论文近期在线发表于《循环》(Circulation)杂志。

研究者们通过运动加速器客观检测了“西班牙社区健康研究/拉丁裔研究”中来自美国4个城市12083例18-74岁人群久坐时间和多种心脏代谢生物指标的相关性。久坐时间(<100计数/分钟)被标准化到的佩戴时间16小时/天。平均久坐时间为11.9小时/天。

结果显示，校正中度至剧烈体力活动和混杂变量后，久坐时间延长与高密度脂蛋白胆固醇(HDL-C)减少有关(P=0.04)，还与甘油三酯水平、餐后2小时血糖和餐后血胰岛素水平以及胰岛素抵抗指数增加有关(所有P值均<0.0001)。这些相关性在不同年龄、性别、西班牙裔和拉丁裔背景以及体力活动水平下依然存在普遍的一致性。即使是在那些满足指南推荐体力活动量的个体中，久坐时间也与若干心脏代谢生物指标(舒张压、HDL-C、空腹和餐后2小时血糖、空腹血胰岛素和胰岛素抵抗指数，所有P值均<0.05)存在有害的关系。

参考文献：Qibin Qi,et al.CIRCULATIONAHA.115.016938Published online before print September 28, 2015,doi: 10.1161/CIRCULATIONAHA.115.016938

Objectively-Measured Sedentary Time and CardiometabolicBiomarkers in U.S. Hispanic/Latino Adults: The HispanicCommunity Health Study/Study of Latinos (HCHS/SOL)
1. Qibin Qi1*;
2. Garrett Strizich1;
3. Gina Merchant2;
4. Daniela Sotres-Alvarez3;
5. Christina Buelna2;
6. Sheila F. Castañeda2;
7. Linda C. Gallo2;
8. Jianwen Cai3;
9. Marc D. Gellman4;
10. Carmen R. Isasi1;
11. Ashley E. Moncrieft4;
12. Lisa Sanchez-Johnsen5;
13. Neil Schneiderman4;
14. Robert C. Kaplan1
-Author Affiliations
1. 1Albert Einstein College of Medicine, Bronx, NY
2. 2San Diego State University, San Diego, CA
3. 3University of North Carolina, Chapel Hill, NC
4. 4University of Miami, Miami, FL
5. 5University of Illinois at Chicago, Chicago, IL
1. ↵* Department of Epidemiology and Population Health, Albert Einstein College ofMedicine, 1300 Morris Park Avenue, Bronx, NY 10461 qibin.qi@einstein.yu.edu
Abstract
Background—Sedentary behavior is recognized as a distinct construct from lackof moderate-vigorous physical activity and is associated with deleterious healthoutcomes. Previous studies have primarily relied on self-reported data, while data on the relationship between objectively-measured sedentary time andcardiometabolic biomarkers are sparse, especially among U.S.Hispanics/Latinos.
Methods and Results—We examined associations of objectively-measured sedentary time (via Actical accelerometers for 7 days) and multiplecardiometabolic biomarkers among 12,083 participants, aged 18-74 years, from the Hispanic Community Health Study/Study of Latinos.Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 U.S. cities between 2008 and 2011.
Sedentary time (<100 counts/minute) was standardized to 16-hour/day of wear time. The mean sedentary time was 11.9 hours/day (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary timewas associated with decreased high-density lipoprotein (HDL)-cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin and HOMA-IR (all P<0.0001). These associations were generally consistent across age, sex,Hispanic/Latino backgrounds, and physical activity levels. Even amongindividuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, HDL-cholesterol, fasting and 2-hour glucose, fasting insulin and HOMA-IR; allP<0.05).
Conclusions—Our large population-based, objectively-derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in U.S. Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for theprevention of cardiometabolic diseases, even in those who meet physical activity recommendations.