在日裔美国人中，CT扫描下的腹内脂肪面积与高血压患病率和发生率呈正相关关系。来自其他人群的证据提示其他区域的脂肪可能具有保护性。美国学者评估了特定脂肪变化是否可预测高血压进展。结果表明，在亚裔美国人中，高血压进展风险与腹内脂肪堆积有相关性，而非股部或腹部皮下脂肪的增加。相关论文近期发表于《高血压》(HYPERTENSION)杂志。

        研究者们前瞻性随访了286例受试者，平均年龄为49.5岁，男性占50.4%，受试者基线时无高血压，也未使用降压药或降糖药。通过CT直接测量基线和5年时受试者的股中部皮下脂肪面积、腹部皮下脂肪面积和腹中部脂肪面积。利用逻辑回归评估10年期间相对脂肪面积5年变化的高血压发生率。

        结果显示，校正年龄、性别、体质指数、基线腹内脂肪、酒精使用、吸烟状态和每周锻炼的能量消耗后，每5年增加的腹内脂肪相对应的高血压相对比值为1.74。在校正基线空腹血胰岛素和2小时血糖水平或188bet在线平台网址 和188bet在线平台网址 前期分类后，该相关性仍保持显著性。而基线和股部或腹部皮下脂肪面积的变化与高血压发生无显著相关性。

        参考文献：Catherine A. Sullivan, et al.HYPERTENSIONAHA.114.04990Published online before print May 11, 2015,doi: 10.1161/HYPERTENSIONAHA.114.04990

Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans
1. Catherine A. Sullivan,
2. Steven E. Kahn,
3. Wilfred Y. Fujimoto,
4. Tomoshige Hayashi,
5. Donna L. Leonetti,
6. Edward J. Boyko
+Author Affiliations
1. From the General Medicine and Hospital and Specialty Medicine Services, Veterans Affairs Puget Sound Health Care System, Seattle, WA (S.E.K., E.J.B.); Division of Endocrinology, Metabolism and Nutrition, Department of Medicine (C.A.S., S.E.K.) and Department of Anthropology (D.L.L.), University of Washington, Seattle; Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City University, Osaka, Japan (T.H.); and the Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington (E.J.B.).
1. Correspondence to Edward J. Boyko, VA Puget Sound (S-123-PCC), 1660 S Columbian Way, Seattle WA 98108. E-mail: eboyko@uw.edu
Abstract
In Japanese Americans, intra-abdominal fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other fat areas may be protective. We sought to determine whether a change in specific fat depots predicts the development of hypertension. We prospectively followed up 286 subjects (mean age, 49.5 years; 50.4% men) from the Japanese American Community Diabetes Study for 10 years. At baseline, subjects did not have hypertension (defined as blood pressure ≥140/90 mm Hg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous fat area, abdominal subcutaneous fat area, and intra-abdominal fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in fat area. The relative odds of developing hypertension for a 5-year increase in intra-abdominal fat was 1.74 (95% confidence interval, 1.28–2.37), after adjusting for age, sex, body mass index, baseline intra-abdominal fat, alcohol use, smoking status, and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes mellitus and pre–diabetes mellitus classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous fat areas and incident hypertension.
In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of intra-abdominal fat rather than the accrual of subcutaneous fat in either the thigh or the abdominal areas.