既往研究已证实，188bet在线平台网址 人群的心血管风险高于无188bet在线平台网址 人群。在188bet在线平台网址 人群中进行动态血压监测(ABPM)正在普及。在正常人群中，夜间收缩压被一致证明是心血管风险的强有力预测因素。近期发表于《高血压杂志》(Journal of Hypertension)的一项研究表明，夜间收缩压也是188bet在线平台网址 患者心血管死亡的显著预测因素。

        研究在基线时纳入了11 291例未接受抗高血压药物治疗的患者(男性5326例，平均年龄54.6岁)，受试者接受ABPM。利用国家计算机登记系统确定受试者的死亡和死亡率结局。在对859例平均随访时间达5.3年的188bet在线平台网址 患者中，死亡74例。

        结果显示，与无188bet在线平台网址 受试者相比，那些有188bet在线平台网址 受试者的日间和夜间收缩压分别为146.4 mmHg vs. 145.1 mmHg (P = NS)和131.2mmHg vs. 126.4 mmHg (P < 0.0001)。较多的188bet在线平台网址 患者存在非勺型夜间收缩压情况(47.4 vs. 35.5%;P ≤ 0.0001)。

        在Cox比例风险模型中，校正性别、年龄、吸烟史、既往心血管事件、体质指数(BMI)和日间收缩压后，夜间收缩压是188bet在线平台网址 患者心血管死亡率的独立预测因素。夜间收缩压增加10 mmHg所致的总心血管、卒中和心脏死亡的危险比分别为1.32 (1.12-1.69)、1.95(1.18-3.20)和 1.24(0.99-1.56)。

参考文献：Draman, Mohd S,et al. J Hypertens. 2015 Apr 16. [Epub ahead of print] .doi: 10.1097/HJH.0000000000000576

J Hypertens. 2015 Apr 16. [Epub ahead of print] .doi: 10.1097/HJH.0000000000000576
Original Article: PDF Only
The importance of night-time systolic blood pressure in diabetic patients: Dublin Outcome Study.
Draman, Mohd S.; Dolan, Eamon; van der Poel, Lelane; Tun, Tommy Kyaw; McDermott, John H.; Sreenan, Seamus; O’Brien, Eoin
Published Ahead-of-Print

Abstract
Objective: Diabetic patients exhibit a higher cardiovascular risk compared to people without diabetes. The use of ambulatory blood pressure monitoring (ABPM) is gaining popularity in this population. Night-time SBP has consistently been shown to be a potent predictor of cardiovascular risk in the normal population. We studied the predictive value of night-time ABPM in a cohort of diabetic patients.
Research design and methods: At baseline, when not on antihypertensive medication, 11 291 patients (5326 men, mean age 54.6 years) underwent ABPM. Using a computerized national registry of death, mortality outcome was ascertained. Among 859 diabetic patients with a mean follow-up of 5.3 years, there were 74 deaths.
Results: Compared to people without diabetes, those with diabetes had daytime and night-time SBP of 146.4 vs. 145.1 (P = NS) and 131.2 vs. 126.4 mmHg (P < 0.0001), respectively. As a consequence, more diabetic patients had a non-dipping night-time SBP profile (47.4 vs. 35.5%; P = < 0.0001). In a Cox proportional-hazards model, night-time SBP was an independent predictor of cardiovascular mortality in diabetic patients after adjustment for sex, age, smoking history, previous cardiovascular events, BMI and daytime SBP. The resultant hazard ratio for a 10-mmHg increase in night-time SBP for total cardiovascular, stroke and cardiac mortality was 1.32 (1.12-1.69), 1.95 (1.18-3.20) and 1.24 (0.99-1.56), respectively.
Conclusion: Night-time SBP is a significant predictor of cardiovascular mortality in patients with diabetes.