相约罗马，直击ESC2016~

        《中国医学论坛报》ESC专题策划

        敢称自己是全球最大、最有影响力的心血管盛会，ESC并非随便说说!看看这些傲人的数据。

        2015年在伦敦召开的ESC吸引了全球32758名专家学者。

        上万篇投稿夯实了ESC的学术基础。

        每年ESC新研究和新指南的发布都是重头戏。今年有30项研究入选HOT LINE，在6个专场发布。

        专场一、Heart failure and innovative approaches(主会场，8月28日11:00~12：30)

        首先登场的DANISH 丹麦随机对照多中心研究，旨在评估非缺血性收缩期心衰患者置入ICD的有效性。

        •DANISH-A Danish randomized, controlled, multicenter study to assess the efficacy of Implantable cardioverter defibrillator in patients with non-ischemic systolic heart failure on mortality

        接下来是两项心衰患者心脏电子置入装置远程监测的研究。

        •REM-HF - Remote monitoring: an evaluation of implantable devices for management of heart failure patients

        •MORE-CARE - Effects of remote monitoring on outcomes and use of healthcare resources in heart failure patients with biventricular defibrillators

        紧随其后的两项研究将探讨干细胞治疗心衰、非缺血性心肌病的有效性和安全性。其中，CHART-1研究是全球首个心脏修复干细胞治疗心衰的3期研究，结果值得期待。

        •CHART-1 - Phase 3 congestive heart failure cardiopoietic regenerative therapy

        •Safety and efficacy of intravenous infusion of ischemia tolerant allogeneic mesenchymal stem cells in patients with non-ischemic cardiomyopathy

        专场二、Preventive strategies 1(主会场，8月28日16:30~18:00)

        冠心病的抗栓治疗是临床中的重要话题，NIPPON研究将探讨生物可吸收聚合物药物洗脱支架最佳双抗时间，ANTARCTIC研究将评估血小板功能监测对老年患者治疗[普拉格雷常规剂量(5 mg)或调整剂量]的指导价值，尤其是对出血事件的预防。

        •Optimal dual antiplatelet treatment (DAPT) duration following drug eluting stent with bioabsorbable polymer and abluminal coating, NIPPON study

        •ANTARCTIC - Platelet function monitoring in elderly patients stented for an acute coronary syndrome

        在这个专场也能了解到两项最新的预防策略：持续正压通气(CPAP)治疗睡眠呼吸暂停(OSA)对心血管病的预防作用;难治性高血压治疗新方法——正中神经调节。

        •SAVE - The sleep apnea cardiovascular endpoints study results

        •Median nerve modulation: A novel approach to resistant hypertension

        此外，NACIAM研究将探讨接受PCI的STEMI患者早期使用NAC(N乙酰半胱氨酸)的作用。

        •NACIAM Trial - The early use of N-acetylcysteine (NAC) with GlycerylTrinitrate (GTN) in ST-segment Elevation Myocardial Infarction patients undergoing primary percutaneous coronary intervention

        专场三、Prevention and lipids(主会场，8月29日11:00~12：30)

        预防与血脂专场最值得期待的研究或许是HIJ-PROPER，该研究旨在探讨，以不同的LDL-C目标值为导向进行降胆固醇治疗，对主要复合终点事件的影响。

        •HIJ-PROPER - LDL cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidemia

        另一项值得关注的研究是关于心血管病康复的OPTICARE研究，将比较不同康复治疗方案对患者预后的影响。

        •OPTICARE - Benefits of the OPTImalCArdiacREhabilitation trial: a randomized, controlled superiority trial of an expanded educational and behavioral intervention

        ESCAPE研究也不容错过，这项3期临床研究将观察PCSK9抑制剂alirocumab对脂蛋白清除的作用。

        •ESCAPE - Effect of alirocumab on the frequency of lipoprotein apheresis: a randomised Phase III trial

        此外，该专场还有在难治性心绞痛中观察脂蛋白清除/去除疗法的随机对照试验，以及观察长时间处于低LDL-C、低收缩压状态对心血管风险的影响。

        •Apheresis as a novel treatment for refractory angina with raised lipoprotein(a): a randomised controlled trial

        •A naturally randomized trial comparing the effect of long-term exposure to lower LDL-C, lower SBP, or both on the risk of cardiovascular disease

        专场四、Coronary artery disease and imaging(主会场，8月29日16:30~18:00)

        影像学检查在冠心病诊治中的应用价值日益受到重视，ESC专门开辟了冠心病与影像学专场。CONSERVE研究在稳定可疑冠心病患者中比较冠脉CTA指导下的选择性介入策略与直接冠脉造影策略的有效性、安全性与经济效益。DOCTORS研究希望能够回答“OCT能否优化支架植入效果”，PACIFIC研究头对头比较冠脉CT血管造影、心肌灌注SPECT、PET、混合成像在缺血性心脏病中的诊断作用。

        •CONSERVE - Direct catheterization versus selective catheterization guided by Coronary Computed Tomography in patients with stable suspected Coronary Artery Disease

        •DOCTORS - Does Optical Coherence Tomography Optimise Results of Stenting?

        •PACIFIC trial - Head-to-head comparison of coronary CT angiography, myocardial perfusion SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease

        此外，CE-MARC 2研究和AMERICA研究也将公布最新结果。

        •CE-MARC 2 - A randomized trial of 3 diagnostic strategies in patients with suspected coronary heart disease.

        •AMERICA - Systematic detection and management of multivascular involvement of atherothrombosis in coronary patients in comparison with treatment of coronary disease only

        专场五、Coronary artery disease and stenting(主会场，8月30日11:00~12：30)

        在冠心病与支架专场，PRAGUE -18研究中替格瑞洛与普拉格雷“狭路相逢”，在STEMI急诊PCI中，谁能获得更好成绩，我们拭目以待。

        •PRAGUE -18 - Randomized comparison of ticagrelorversus prasugrel in ST elevation myocardial infarction

        复杂分叉病变中常常需要用到双支架术式，裙裤术和T支架术是最常用的双支架术，二者安全性和疗效是否相当?BBKⅡ研究或许能给我们一些提示。

        •BBK Ⅱtrial - Culotte versus T-stenting for treatment of coronary bifurcation lesions

        在药物洗脱支架独占风头的当下，金属裸支架还有用武之地吗?期待NorStent和BASKET-SAVAGE两项4期临床研究的最新结果。

        •NorStent - Comparison of long term effects of new generation DES vs contemporary BMS on mortality, morbidity, revascularization, and quality of life

        •BASKET-SAVAGE - Drug-eluting vs. bare metal stents in saphenous vein grafts

        斑块侵蚀导致的急性冠脉综合征能否避免支架植入?

        •Can patients with acute coronary syndromes caused by plaque erosion be treated with anti-thrombotic therapy without stenting?

        六、Preventive strategies 2(主会场，8月30日14:00~15:30)

        last but not the least，在预测策略2专场亮相的将有新型口服抗凝药依度沙班、Xa因子抑制剂的“解药”Andexanetalfa、TAVR脑保护装置……

        •ENSURE-AF study: Edoxaban for cardioversion of atrial fibrillation

        •ANNEXA-4 –Andexanetalfa for reversal of Factor Xa inhibitors in patients with acute major bleeding

        •REVERSE II - Multi-national validation of the men continue and HERDOO2 rule to identify low risk unprovoked venous thromboembolism patients who can discontinue anticoagulants

        •SENTINEL trial - A randomized multicenter trial of cerebral protection in TAVR

        •YEARS - Safety and efficiency of a simplified diagnostic management algorithm for 3500 patients with clinically suspected acute pulmonary embolism.

        码了这么多字，希望能对同样关注本次ESC的各位看官有一点帮助。

        您觉得哪项研究最值得期待，或者关于这些研究领域，您有哪些疑问或困惑，欢迎您留言分享，让我们帮您去问专家吧~