晨峰血压(Morning BP Surge:MBPS)是指人体在清醒时常出现血压升高。既往数据显示，MBPS高于正常值与靶器官损害(包括左心室肥厚和蛋白尿)有关。但鲜有研究表明升高的MBPS与慢性肾脏疾病的相关性。因此，土耳其学者们对上述问题进行了研究。

        该项研究入组了622例接受动态血压检测同时存在MBPS的原发性高血压患者，平均年龄为57.6±12.4岁，男性54.0%，合并188bet在线平台网址 患者占16.7%，既往有心血管疾病的患者占10.6%。对其中位随访3.33年。

        结果显示，在随访期间，32例患者进展为CKD。持续和分类变量分析显示，MBPS较高与CKD的发生有关。升高的MBPS与肾功能恶化以及进展为CKD均有相关性。发生这种相关性的潜在机制尚需进一步研究。

        相关论文近期发表于《临床高血压杂志》(The Journal of Clinical Hypertension.)

        参考文献：Osman Turak,et al.The Journal of Clinical Hypertension.DOI: 10.1111/jch.12707.

Morning Blood Pressure Surge as a Predictor of Development of Chronic Kidney Disease

Blood pressure (BP) usually increases upon awakening––a physiological mechanism called morning BP surge (MBPS).BP values above the MBPS threshold are associated withtarget organ damage, including left ventricular hypertrophy and proteinuria. Despite these data, there have been no studies that have investigated the association between elevated MBPS and the development of incident chronic kidney disease (CKD). In this study, patients with essential hypertension were included and underwent ambulatory BP measurements and MBPS. Patients were followed for a median of 3.33 years. In total, 622 patients were enrolled.

The mean age of patients was 57.6
12.4 years, 54.0% were men, 16.7% had diabetes, and 10.6% had prevalent
cardiovascular disease. During follow-up, 32 patients developed CKD. Higher MBPS, analyzed both as continuous and categorical variables, was associated with incident CKD in all models. Elevated MBPS is associated with kidney function deterioration and the development of CKD. Studies are needed to further examine underlying mechanisms regarding MBPS and these renal outcomes.